این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۰، شماره ۳، صفحات ۲۰۶-۲۱۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Streptozotocin Induced Acute Clinical Effects in Rabbits (Oryctolagus cuniculus)
چکیده انگلیسی مقاله Background & Objectives: Streptozotocin (STZ) is used for induction of Type-1 diabetes mellitus in animal models. Its beta-cytotoxic action results in sudden release of insulin leading to severe hypoglycaemia and even mortality. However, its sensitivity varies with species. Present investigation was aimed at studying STZ induced acute clinical effects in rabbits. Methods: Streptozotocin@ 65 mg/kg b.w.was administered to thirteenNew Zealand White rabbits, 1-1.5 kg body weight, as single intravenous dose in 1mL citrate buffer, pH 4.6. Blood glucose levels were recorded before drug administration and then at 20 min, 1h, and hourly up to 9 hours post-treatment followed by intravenous and oral glucose therapy. Clinical signs were noted. Results: STZ caused immediate hyperglycaemia up to 4 hours, and then progressively severe hypoglycaemia up to 9 hours. Hypoglycaemia caused characteristic behavioural alterations including lethargy, dullness, sitting quietly but appearing alert, followed by aesthesia and then muscular weakness with characteristic postural changes starting from drooping of head and torticollis, Rabbits recovered following glucose therapy. Marked individual variations in response vis-a-vis onset and severity of glycaemic changes were observed. Conclusion: STZ induced a characteristic multiphasic immediate response in rabbits similar to one reported in other rodents. Behavioural changes were characteristic of hypoglycaemia warranting early management in order to avoid fatalities. How to cite this article: Saleem Mir M, Maqbool Darzi M, Baba OK, Musadiq Khan H, Ahmad Kamil S, Sofi AH, et al. Streptozotocin Induced Acute Clinical Effectsin Rabbits (Oryctolagus cuniculus). Iran J Pathol. 2015;10(3):206-13.
کلیدواژه‌های انگلیسی مقاله Signs And Symptoms,Experimental Model,Rabbits,streptozotocin
نویسندگان مقاله مسعود saleem میر | saleem mir
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

محمد maqbool درزی | maqbool darzi
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

omer خلیل بابا | omer khalil
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

hilal musadiq خان | musadiq khan
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

shayaib احمد کامل | ahmad kamil
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

asif حسن صوفی | asif hassan
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

sarfraz احمد wani | sarfraz ahmad
division of veterinary pathology, f.v.sc. amp; a.h, sher-e-kashmir university of agricultural sciences and technology of kashmir, kashmir j amp;k , india

نشانی اینترنتی http://ijp.iranpath.org/article_11611_efd2dce0f911896a79627cb6361c64b4.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات