این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱۰، شماره ۲، صفحات ۱۳۶-۱۴۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparison of Serum Autoantibodies to Desmogleins I, III in Patients with Oral Lichen Planus and Healthy Controls
چکیده انگلیسی مقاله Background & Objective: Lichen planus is a mucocutaneous disease which is relatively common and in 30-70% of patients, mucosal lesions can be seen and known as a precancerous lesion but its etiology is not completely understood. Desmogleins I and III are the main desmosomal transmembrane proteins. These proteins have been identified as the autoantigen of the autoimmune disease. The aim of this study was evaluation of serum autoantibodies against desmogleins Ι, ΙΙΙ in oral lichen planus. Methods: We attempted to determine the etiology of this disease with evaluation of these serum factors. Thirty-five patients with oral lichen planus and 35 healthy controls were recruited and tested for serum autoantibodies against desmogleins Ι, ΙΙΙ and indirect immunofluorescence also performed. Data were analyzed by statistical–analytical methods (Independent sample t-test) with using the SPSS.15 software. Results: Serum autoantibody against desmoglein Ι had no significant difference in the two groups (P=0.31) but significant increase in serum autoantibody to desmoglein ΙΙΙ was found in patients with oral lichen planus (P=0.00). Conclusion: It seems that autoantibody against desmoglein III has a significant role in the pathogenesis of oral lichen planus.
کلیدواژه‌های انگلیسی مقاله Lichen Planus,Desmogleins I,III,Serum Level
نویسندگان مقاله نرگس قلی زاده |
dept. of oral and maxillofacial medicine, faculty of dentistry, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین khoini پورفر | khoini poorfar
dept. of pediatric hematology and oncology, hamadan university of medical science, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

علی تقوی زنوز | taghavi zenouz
dept. of oral and maxillofacial medicine, faculty of dentistry, tabriz university of medical sciences, tabriz
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

معصومه وطن دوست |
dept. of pediatric dentistry, tabriz university of medical science, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

معصومه مهدی پور |
dept. of oral and maxillofacial medicine, faculty of dentistry, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://ijp.iranpath.org/article_9731_ad4125431dafaf02d0c3b70ca79c55a5.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات