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Iranian Journal of Pathology، جلد ۹، شماره ۲، صفحات ۱۳۸-۱۴۸
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عنوان انگلیسی Antioxidant and Antiepileptic Activity of 1-[1-(3-Methoxyphenyl) (Tetralyl)] Piperidine as a New Derivative of Phencyclidine on Pentylentetrazole-Induced Kindling Mice
چکیده انگلیسی مقاله Background and Objective: N-Methyl-D-aspartate (NMDA) antagonists such as piperidines are the most important antiepileptic drugs. Considering the fact that piperidine derivatives such as phencyclidine (PCP) and its new derivative, 1-[1-(3-methoxyphenyl) (tetralyl)] piperidine (PCP1), have different potencies, the antiepileptic effects of mentioned drugs were investigated in the present study. Methods: Fifty male mice weighing 25-30 g were randomly selected and divided into five experimental groups: 1- Control 2- Pentylentetrazole-kindled mice, 3- Positive control group which received valproate, and groups 4 and 5, which received PCP and PCP1, respectively. Kindling was down by 11 periods injection of PTZ every second day for 22 days. At the 12th injection, all kindled group were tested for PTZ challenge dose. The exhibited phases of seizure (0-6) were observed and noted till 30 minutes after PTZ injection. Finally, the malondialdehyde, superoxide dismutase and nitric oxide levels of the animal’s brain tissues were determined and compared with others. Results: PCP1 could have a prominent anti-convulsion effect compared to PCP, especially in the reduction of phase 2 duration time and seizure score in challenge dose. Our additional experiments showed that there was a significant reduction in NO level in PCP1 treated animals. Conclusion: Administration of the new piperidine derivate, PCP1 could have yielded a prominent anti-convulsion effect in grand epilepsy. Regarding to the changes in conformation of PCP1 as a non-competitive antagonist of NMDA receptor, it may block the NMDA receptors potentially more effectively than phencyclidine.
کلیدواژه‌های انگلیسی مقاله Antioxidant Effect,Antiepileptics,Phencyclidine,Mice
نویسندگان مقاله زهرا کیاسالاری |
neurophysiology research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

محسن خلیلی |
neurophysiology research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

مهرداد روغنی |
neurophysiology research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

عباس احمدی |
dept. of chemistry, faculty of science, islamic azad university, karaj branch, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)

منیره mireie |
traditional medicine clinical trial research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی کرج (Islamic azad university of karaj)

نشانی اینترنتی http://ijp.iranpath.org/article_7809_88006e630616ce422cf422796f8e3e73.pdf
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