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Iranian Journal of Pathology، جلد ۷، شماره ۲، صفحات ۱۰۷-۱۱۱

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عنوان انگلیسی Searching the Human Herpes 6, 7 (PCR) In CSF of Children Admitted In Pediatric Ward of Rasoul Hospital, Tehran, Iran
چکیده انگلیسی مقاله Background and Objectives: Meningoencephalitis in Iranian children is frequent, but encephalitis is rare .The frequency of HHV-6 and HHV-7 in central nervous system diseases of our children is unclear. The aim of this study was searching the DNA-s of HHV-6 & HHV-7 in CSF samples of children with meningoencephalitis Materials and Methods: A cross sectional study (2007-2009) was done in Pediatric Ward in Rasoul Hospital, Tehran Iran. Totally, 150 CSF samples obtained from children (1-180 months) with meningoencephalitis. Conventional and BACTEC Ped Plus medium, latex agglutination tests were used for ruling out the bacterial causes. We searched the DNA-s of HHV-6 & HHV-6 quantitatively by Real time - PCR in 150 CSF samples obtained from children with meningoencephalitis. Results: 60.7 % of cases were male. Fever was reported (>38.5) in 74%; irritability in 70%; Convulsion was seen in 53% of cases. Herpes virus was detected in 12% (18/150) of cases. Both HHV-6 & HHV-7 were found in 6% of all cases. HHV-6 DNA was detected in 4.7% (6) and HHV-7 DNA was detected in 2 cases (1.4%) without any correlation to age, sex and clinical signs. HHV-6 was slightly more frequent than HHV-7. Conclusion: Our data indicate that herpes viruses are not uncommon causes in children with meningoencephalitis. The incidence was lower than other references.
کلیدواژه‌های انگلیسی مقاله Cerebrospinal Fluids,Herpes viruses,PCR

نویسندگان مقاله فریده ابراهیمی تاج | ebrahimi taj
dept. of infectious disease, research center of pediatric infectious diseases, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ثمیله نوربخش |
dept. of infectious disease, research center of pediatric infectious diseases, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حمیدرضا منوری | hamid reza
dept. of virology, research center of pediatric infectious diseases, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آذردخت طباطبایی |
dept. of microbiology, research center of pediatric infectious diseases, tehran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

معصومه bakhshyeh |
dept. of microbiology, research center of pediatric infectious diseases, tehran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)


نشانی اینترنتی http://ijp.iranpath.org/article_8367_beb932f1ac7f2b6b8ff24e5b603de479.pdf
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