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Iranian Journal of Pathology، جلد ۶، شماره ۲، صفحات ۸۶-۹۲
عنوان فارسی
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عنوان انگلیسی Immunohistochemical Study of HER2/neu Overexpression in Adenoid Cystic Carcinoma of Salivary Glands
چکیده انگلیسی مقاله Background and Objectives: Adenoid cystic carcinoma (ACC), the most common malignant tumor of submandibular and minor salivary glands, is characterized by a high rate of local recurrence and distant hematogenous metastasis and tendency to invade peripheral nerves. In spite of radiotherapy and surgical treatment, the long-term prognosis is dismal. Today, many studies are being conducted using the immunohistochemical markers to help in the evaluation of ACC prognosis. The present investigation was performed to survey immunohistochemically HER2/neu over expression in adenoid cystic carcinoma of salivary glands. Materials and Methods: The 24 existing samples of formalin-fixed paraffin embedded specimen were stained with HER2/neu markers. Tumors with moderate (2+) to strong (3+) complete membrane staining in at least 10% of the tumor cells were scored as positive for over expression. Results: The overall frequency of over expression for HER2/neu was 45.8% and 11 specimen were positive for HER2/neu expression. A significant relationship was found between HER2/neu over expression and grade of ACC. No significant relationship was detected between immunostaining of HER2/neu and histologic pattern. Conclusion: HER2/neu immunostaining might be reliable and useful for evaluation of ACC prognosis.
کلیدواژه‌های انگلیسی مقاله Adenoid Cystic Carcinoma,HER2/neu,Immunohistochemistry
نویسندگان مقاله جهانشاه صالحی نژاد |
dept. of oral and maxillofacial pathology, faculty of dentistry and dental research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

بهاره جوشن |
dept.of endodontics, faculty of dentistry and dental research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امیرحسین جعفریان | amir hossein
dept. of pathology, ghaem hospital, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عباسعلی امیدی | abbas ali
dept. of pathology, ghaem hospital, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijp.iranpath.org/article_8553_4f0cfbc59c7a99a042f3ab3a0ce0560a.pdf
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