این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۴، شماره ۲، صفحات ۷۱-۷۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association between Hepatitis B Virus Infection Outcome and HLA-A and DRB1 Genotyping in North Part of Iran
چکیده انگلیسی مقاله Background and Objective: The outcome of hepatitis B virus (HBV) infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRB1 alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey in certain HLA alleles that were significantly related to the outcome of HBV infection. The current study aimed to determine association between HBV infection outcome and HLA-A and DRB1 genotyping in North part of Iran. Patients and Methods: Ninety-four HBV infected patients were enrolled in this cross sectional study. First HLA-A and DRB1 alleles were analyzed by using low resolution PCR sequence-specific-primer (PCR-SSP) and then we used high resolution PCR-SSP method for subtyping HLA-A*33 and DRB1*13 alleles which were significantly related to the outcome of HBV infection. Results: HLA-A*33 allele was significantly higher in persistent group than recovered group and sub typing showed HLA-A*3303 in 75% and HLA-A*3301 in 25% of cases. HLA-DRB1*13 allele was significantly lower in persistent group than in recovered group and its subtypes were DRB1*1301 in 66.7% and DRB1*1303 in 33.3% of subjects. Conclusion: Host HLA polymorphism is an important factor to determining the outcome of HBV infection. HLA-A*3303 and DRB1*1301 were the predominant subtypes of HLA-A*33 and DRB1*13 alleles in Iranian HBV infected patients.
کلیدواژه‌های انگلیسی مقاله Hepatitis B,HLA Antigens,Polymerase Chain Reaction
نویسندگان مقاله آمیتیس رمضانی |
clinical research dept., pasteur institute of iran, tehran, iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

علی اسلامی فر |
clinical research dept., pasteur institute of iran, tehran, iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

آرزو آقاخانی |
clinical research dept., pasteur institute of iran, tehran, iran
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

ابراهیم کلانتر |
school of allied medical sciences, iran medical university, tehran, iran

محمد بنی فضل |
iranian society for support patients with infectious disease, tehran, iran

اکبر ولایتی |
dept. of pediatric, masih daneshvari hospital, tehran, iran

نشانی اینترنتی http://ijp.iranpath.org/article_8971_e7efcb9030c28d4c6e556f006d406917.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات