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Iranian Journal of Pathology، جلد ۴، شماره ۱، صفحات ۵-۸
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عنوان انگلیسی Mid-Trimester Amniotic Fluid High Sensitive C-Reactive Protein Level in the Prediction of Preterm Delivery
چکیده انگلیسی مقاله Background and Objectives: Preterm labor is a serious problem in obstetrics, accounting for 70% of perinatal mortality. High sensitive C - reactive protein (HS-CRP) is a sensitive marker of Inflammation. Our aim in this study was to determine Amniotic fluid hs-CRP concentration and its correlation with pre-Term delivery. Materials and methods: This prospective study was conducted on 90 pregnant women who underwent genetic amniocentesis between the 15th and 20th weeks of gestation. All patients were followed until delivery. Pateints with abnormal karyotype and iatrogenic preterm delivery for fetal and maternal indications were excluded. The samples were carried immediately to the laboratory of Imam Khomaini Hospital Complex, Tehran, Iran for cytogenetic examination and tested for HS-CRP by turbidimetric method. Non parametric tests and receiver-operating characteristics curve analysis were used for statistical purpose. Results: The study showed no correlation between amniotic fluid HS-CRP concentrations with preterm delivery. Maternal serum alpha-fetoprotein (AFP) levels were higher in patients delivered preterm compared with term deliveries (P=0.036). Conclusion: Our results implicated that HS-CRP like other acute phase response markers was not as a possible risk marker of preterm delivery.
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نویسندگان مقاله علیرضا عبداللهی |
dept. of pathology, tehran university of medical sciences, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

صدیقه برنا |
dept. of obstetrics and gynecology, fetal- maternal medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه میرزایی |
dept. of obstetrics and gynecology, kerman university of medical science, kerman ,iran

اکرم sarbiaei |
dept. of clinical laboratory, imam hospital laboratory, tehran, iran

نشانی اینترنتی http://ijp.iranpath.org/article_8989_8e7b220cdf1645c1751074fcf4d616f8.pdf
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