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Iranian Journal of Pathology، جلد ۳، شماره ۴، صفحات ۱۷۹-۱۸۲
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عنوان انگلیسی Correlation Between Soluble Vascular Endothelial Growth Factor A, Its Receptor 1 And Response To Chemotherapy In Acute Leukemia In Children
چکیده انگلیسی مقاله Background and Objective: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and R2) are major regulators of angiogenesis. This study was designed to assess serum levels of VEGF and VEGF-R1 and their prognostic significance in newly diagnosed childhood acute leukemia. Materials and Methods: For this purpose, VEGF and VEGF-R1 were determined using enzyme linked immuno-sorbant assay (ELISA) in samples obtained before treatment. Demographic data were recorded. Bone marrow blast percentage was counted on diagnosis and 2 weeks after induction therapy. A p value less than 0.05 considered significant. Results: Fifty-three children (22 boys and 31 girls) with newly diagnosed acute leukemia were enrolled in the study. Most cases (56.6%) were pre B cell ALL. Mean value of VEFG-A in good responders was 55.13 ± 24.96 pg/ml and in poor responders it was 94.46 ± 15.75 (p0.05). Using ROC curve, we found out a cut-off point of 76 pg/ml to discriminate poor response to chemotherapy. Conclusion: Soluble VEGF-A is an independent factor for response to therapy in childhood leukemia and leukemic patients with sVEGF-A level over 76 pg/ml will have poor response to treatment.
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نویسندگان مقاله میترا مهرآزما |
dept. of pathology, ali-asghar hospital, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

خدیجه ارجمندی رفسنجانی | arjomandi rafsanjani
dept. of pediatric hematology and oncology, iran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

بهزاد torkamanipoor |
iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://ijp.iranpath.org/article_9003_d21a46baa6df6301ae5087e7de0daa00.pdf
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