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Iranian Journal of Pathology، جلد ۳، شماره ۴، صفحات ۲۰۳-۲۰۷
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عنوان انگلیسی Sensitivity And Specificity Of Procalcitonin In Diagnosis Of Neonatal Sepsis
چکیده انگلیسی مقاله Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NICU and neonatal ward in Shahrekord Hajar hospital were enrolled. A full workup including blood cultureand other tests and PCT was conductede. Sensitivity, specificity, positive and negative predictive values for PCT was determined. Results: It was found out that 8 patients had definite infection, 15 patients had possible infection, and 127 patients had no infection. Although PCT was not able to significantly differentiate between those with definite and possible infections (p>0.05), but there was a significant difference for frequency of abnormal PCT between non-infectious patients and other patients. Sensitivity, specificity, positive and negative predictive values of PCT was 87.5%, 87.4%, 30.4%, 99.1%, and 87.41% respectively. Conclusion: Beside the limitation of the sample size, the satisfactory diagnostic characteristics of PCT highlight it as a good measure for diagnosis of neonatal sepsis. Further studies are essential to be carried out.
کلیدواژه‌های انگلیسی مقاله Neonate,Sepsis,Procalcitonin
نویسندگان مقاله ابوالفضل خوشدل |
dept. of pediatrics, shahrekord university of medical sciences, shahrekord, iran.

مهدی محمودزاده |
dept. of internal medicine, shahrekord university of medical sciences, shahrekord, iran.

سلیمان خیری |
dept. of statistics, shahrekord university of medical sciences, shahrekord, iran.

رضا ایمانی |
dept. of infectious diseases, shahrekord university of medical sciences, shahrekord, iran.

قربانعلی شهابی |
dept. of immunology, shahrekord university of medical sciences, shahrekord, iran.

ابراهیم ساعدی |
jondishapoor university of medical siences, ahwaz, iran.

الهام طاهری |
shaharekord university of medical sciences, shahrekord, iran

نشانی اینترنتی http://ijp.iranpath.org/article_9012_409bc51a7c50fc5ab78e1d551de761aa.pdf
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