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Iranian Journal of Pathology، جلد ۲، شماره ۳، صفحات ۸۹-۹۳
عنوان فارسی
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عنوان انگلیسی Detection of Disseminated Mycobactrial Infection Due to BCG Vaccination (BCGosis) in 4 Suspected Infant Autopsies by PCR Method
چکیده انگلیسی مقاله Background and Objective: BCG vaccination is used in many countries with a high prevalence of TB to prevent childhood tuberculosis meningitis and miliary disease. Local and systemic sideeffects are associated with BCG vaccine. The most critical reaction is disseminated BCG infection which occurs in mostly immunodeficient patients. Materials and Methods: We performed 4 autopsies during 2001-2003 which were suspected for BCGosis clinically and histologically by presence of granulomatous foci in several organs with acid fast bacilli. The mycobacteria were identified by PCR. Their DNA was extracted from the tissue blocks, identified with primers which were designed to detect the RD1 deletion. Results: We found BCG genome by PCR in 3 out of 4 patients. These patients had acid fast bacilli in special staining. Conclusion: Since BCGosis is a fatal and uncommon disease, occurring after vaccination with numerous complications, its diagnosis is of paramount importance and should be considered in the appropriate clinical setting.
کلیدواژه‌های انگلیسی مقاله Granuloma,Autopsy,PCR
نویسندگان مقاله فرزانه جدلی |
pedircorg@yahoo.com

عبدالله کریمی |
pediatric infectious research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شهناز آرمین |
pediatric infectious research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

آتوسا غریب |
pediatric infectious research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

فاطمه فلاح |
pediatric infectious research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد شریفیان |
pediatric infectious research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

الهام مظاهری تهرانی | mazaheri tehrani
pediatric infectious research center, shahid beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://ijp.iranpath.org/article_8957_d76bdb47daa3c84b20058666cdb5c8df.pdf
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