این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pathology، جلد ۱، شماره ۳، صفحات ۱۲۱-۱۲۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Determining The Diagnostic Value Of Neuron Specific Enolase Staining Of The Mucosal-submucosal Rectal Biopsies Obtained From Patients Suspected Of Hirschsprung’s Disease
چکیده انگلیسی مقاله Background and Objective: Diagnosis of Hirschsprung’s disease (HD) as the most common cause of neonatal intestinal obstruction is based on the presence of aganglionosis from seromuscular or full thickness biopsy. Due to the complication of full thickness or seromuscular rectal biopsy, mucosal-sub mucosal biopsy is more intended. However, interpretation of these biopsies stained with hematoxylin and eosin (H&E) and even using immunohistochemical (IHC) methods such as acetylcholine esterase is often problematic. Although neuron-specific enolase staining (NSE) is an available and easy method to perform for diagnosis of HD, however, our knowledge on its specificity is not adequate. Therefore, this study was aimed to determine the diagnostic value of NSE on the mucosal-sub mucosal rectal biopsy for the diagnosis of HD and the allied disorders deficit. Materials and Methods: This study was conducted on 65 mucosal-submucosal and 65 seromuscular rectal biopsies (standard) obtained from the patients suspected of HD and allied disorders referred to the Avicena and Shafa hospitals (Sari, Iran) from April 2003 to September 2004. Two biopsies were taken from each patient: the mucosal-submucosal biopsy was stained by NSE and H&E staining was used for seromuscular samples. The prepared slides were observed and evaluated at double blind condition and the results were compared. Results: Sensitivity, specificity, efficiency, positive and negative predictive values in the diagnosis of HD in NSE method were 100%, 84.2%, 89.1%, 81.8%, and 100% respectively (p
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله ژیلا ترابی زاده |
department of pathology, school of medicine, imam hospital, mazandaran university med. sciences, sari
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

فرشاد نقش وار |
department of pathology, school of medicine, imam hospital, mazandaran university med. sciences, sari.
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

علیرضا خلیلیان | ali reza
department of biostatistics, school of medicine, mazandaran university med. sciences, sari.
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

نشانی اینترنتی http://ijp.iranpath.org/article_8917_6631852351bcbc2492f42043b441b736.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات