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Avicenna Journal of Phytomedicine، جلد ۸، شماره ۶، صفحات ۵۴۳-۵۵۱
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عنوان انگلیسی Topical application of Cassia fistula L. fruit gel in management of cutaneous lesions of pemphigus vulgaris: A double-blind, placebo-controlled clinical trial
چکیده انگلیسی مقاله Objective: Cassia fistula L. fruit extract has been traditionally used in the treatment of pemphigus vulgaris (PV) lesions in Iran. The aim of this study was to determine the efficacy of C. fistula fruit gel on healing time of PV lesions in a clinical setting.Materials and Methods: This was a randomized, double-blind placebo-controlled clinical trial that was performed in dermatology ward at Saadi hospital, affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. Right- or left- sided lesions of PV patients on standard systemic treatment were randomized for treatment with either C. fistula fruit gel or placebo prescribed twice daily. The largest diameter of each lesion was measured at the baseline (day 0) and on days 10 and 20. Epithelialization Index (EI), as outcome measure was calculated and compared between the two groups.Results: The present study comprised 20 patients, with overall 82 cutaneous lesions including 41 lesions in the C. fistula fruit gel group and 41 lesions in the placebo group. The EI in the C. fistula fruit gel group was significantly higher than that of the placebo group both on day 10 (65±28vs 30±34; p=0.001) and at the end of the study (91±22 vs 69±49; p=0.003). Conclusion: Topical application of C. fistula fruit gel can be considered as an effective adjuvant therapy in treatment of PV.
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نویسندگان مقاله | Fatemh Atarzadeh
Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Traditional Iranian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Kamalinejad
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Gholam Amin
Department of Pharmacognosy and Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Ali Salehi
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Ladan dastgheib
Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran


| Amir Jaladat
Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Mojtaba Heydari
Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Zahra Gouyandeh
Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://ajp.mums.ac.ir/article_11515.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/232/article-232-954825.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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