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Basic and Clinical Neuroscience، جلد ۶، شماره ۴، صفحات ۲۸۵-۲۹۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Antinociceptive Effects of Hydroalcoholic Extract of Borago Officinalis Flower in Male Rats Using Formalin Test
چکیده انگلیسی مقاله Introduction: Borago officinalis flower (borage) is a known sedative in herbal medicine the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. Methods: Fifty-six adult male albino Wistar rats were randomly divided into seven groups: Control groups of A (intact), B (saline), and C (Positive control) plus test groups of D, E, F, and G (n=8). The groups D, E , and F received 6.25, 12.5, and 25 mg/kg, Borago officinalis flower hydroalcholic extract before the test, respectively but group G received 25 mg/kg borage extract and aspirin before the test. A biphasic pain was induced by injection of formalin 1%. The obtained data were analyzed by SPSS software ver. 17 employing statistical tests of Kruskal- Wallis and Mann-Whitney. The results were expressed as mean±SD. Statistical differences were considered significant at P< 0.05. Results: The results revealed that the acute and chronic pain behavior score in test groups of D, E, F, and G significantly decreased compared to groups A and B, but this score did not show any difference compared to group C. Moreover, chronic pain behavior score in group G was significantly lower than all other groups. Discussion: The results indicated that Borago officinalis hydroalcoholic extract affects the acute and chronic pain behavior response in formaline test male rats.
کلیدواژه‌های انگلیسی مقاله Formalin test, Rat, Pain behavior, Borago officinalis
نویسندگان مقاله محمدرضا شهرکی | mohammad reza shahraki
zahedan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

مهدیه ahmadimoghadm | mahdieh ahmadimoghadm
local studies amp;amp; specialty services of jahad-e-daneshgahi, sistan and baluchistan branch, zahedan, iran.


احمدرضا شهرکی | ahmad reza shahraki
zahedan university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-717-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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