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Basic and Clinical Neuroscience، جلد ۶، شماره ۳، صفحات ۱۵۵-۱۶۲
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عنوان انگلیسی Glucocorticoids Interact with Cholinergic System in Impairing Memory Reconsolidation of an Inhibitory Avoidance Task in Mice
چکیده انگلیسی مقاله Introduction: Recent studies suggest that glucocorticoids modulate memory reconsolidation. Moreover, cholinergic system is involved in memory reconsolidation. Since glucocorticoids interact with brain cholinergic system in modulating memory processing, we investigated whether glucocorticoid influences on the reconsolidation of emotionally arousing training depend on the cholinergic system. Methods: Mice were trained (1mA, 3s footshock) in an inhibitory avoidance task. Forty-eight hours after training, memory reactivation was occurred (Test 1), and different treatments were given. Two (Test 2), five (Test 3), and seven days (Test 4) after memory reactivation (Test 1), animals were retested for fear memory retention. Results: In the first experiment, we observed that administration of corticosterone (CORT, 0.3, 1 and 3 mg/kg) following memory reactivation impaired subsequent expression of memory in a dose-dependent manner. In the second experiment, we found that CORT-induced impairment of memory reconsolidation was reversed by the muscarinic receptor antagonist atropine (0.5 and 2 mg/kg). In the third experiment, the nicotinic receptor antagonist mecaylamine (0.5 or 2 mg/kg) was not able to block the corticosterone response. Discussion: These findings indicate that glucocorticoids impair memory reconsolidation by a muscarinic cholinergic mechanism.
کلیدواژه‌های انگلیسی مقاله Memory reconsolidation, Glucocorticoids, Cholinergic agents
نویسندگان مقاله سمیه امیری | somayeh amiri
semnan


زهرا جعفریان | zahra jafarian
semnan


عباسعلی وفایی | abbas ali vafaei
semnan


علی رشیدی پور | ali rashidy pour
laboratory of learning and memory, physiology research center, department of physiology, school of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

زهرا معتقد لاریجانی | zahra motaghed larijani
semnan


سید افشین سمایی | seyed afshin samaei


نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-72-4&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cognitive Neuroscience
نوع مقاله منتشر شده Original
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