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Basic and Clinical Neuroscience، جلد ۶، شماره ۲، صفحات ۷۳-۸۲
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عنوان انگلیسی The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats
چکیده انگلیسی مقاله Introduction: The hippocampus (HIP), the primary brain structure related to learning and memory, receives sparse but comprehensive dopamine innervations and contains dopamine D1/D2-like receptors. It is demonstrated that dopamine receptors in dentate gyrus (DG) region of HIP have a remarkable function in spatial reward processing. Much less is known about the involvement of HIP and its D1/D2 dopamine receptors in drug-seeking behaviors, more particularly, in the morphine extinguished conditioned place preference (CPP). Methods: To find out the role of D1/D2-like receptors within the DG in morphine-seeking behaviors, forty adult male albino Wistar rats weighing 220-280g were unilaterally implanted by a cannula into the DG. The CPP paradigm was done conditioning score and locomotors activity were recorded by Ethovision software. All drugs/vehicles were microinjected one day after extinction (just before the CPP test) into the DG as reinstatement day. Results: The results showed that intra-DG administration of different dose of SCH23390 (0.25, 1 and 4μg/0.5μl saline), as a selective D1-like receptor antagonist and sulpiride (0.25, 1 and 4μg/0.5μl DMSO), as a selective D2-like receptor antagonist dose-dependently attenuated the morphine-extinguished CPP reinstated by priming injection of morphine (1 mg/kg, sc). Discussion: It can be concluded that D1/D2-like receptors within this region have an important role in morphine-seeking behaviors in extinguished rats.
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نویسندگان مقاله بهروز طالقانی خاکپور | behrooz khakpour taleghani
cellular amp; molecular research center and department of physiology, school of ‎medicine, guilan university of medical sciences, rasht, iran ‎

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

زهرا رییسی | zahra reisi
neuroscience research center, shahid beheshti university of medical sciences, ‎p.o.box 19615-1178, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

عباس حق پرست | abbas haghparast
neuroscience research center, shahid beheshti university of medical sciences, ‎p.o.box 19615-1178, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-744-1&slc_lang=en&sid=en
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