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Basic and Clinical Neuroscience، جلد ۵، شماره ۱، صفحات ۱۱-۱۷
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عنوان انگلیسی Antidepressant Activity of Methanolic Extract of Amaranthus Spinosus
چکیده انگلیسی مقاله Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Amaranthus spinosus was investigation for antidepressant activity. Methods: Antidepressant activity of methanolic extract of Amaranthus spinosus (MEAS) was investigated by using Forced swimming test (FST) and Tail suspension test (TST) models. Escitalopram and Imipramine were used as reference standards. Results: It has been observed from our study that both the MEAS at higher concentration showed significant (p< 0.01) reduction in immobility in tail suspension and forced swim model of depression comparable to Escitalopram and Imipramine. Discussion: However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity.
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نویسندگان مقاله بی بی صدیقه ashok کومار | b s ashok kumar
department of pharmacognosy, sri k.v.college of pharmacy, chickballapur, karnataka,india.


k lakshman | k lakshman
department of pharmacognosy, pes college of pharamcy, bangalore, karnataka, india.


c velmurugan | c velmurugan
department of pharmacology, sree krishna chaitanya college of pharmacy, madanapalle, andhrapradesh, india.


سید محمد sridhar | s m sridhar
department of pharmacology, sree krishna chaitanya college of pharmacy, madanapalle, andhrapradesh, india.


ساران gopisetty | saran gopisetty
department of pharmacology, sri k.v.college of pharmacy, chickballapur, karnataka, india.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-189&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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