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Basic and Clinical Neuroscience، جلد ۵، شماره ۱، صفحات ۸۸-۹۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Detection of Interleukin-19 mRNA in C57BL/6 Mice Astroglial Cells and Brain Cortex
چکیده انگلیسی مقاله Introduction: Astrocytes are the most abundant glial cell type. In addition to their neurological roles, astrocytes also have immune functions. They have been involved in antigen presentation in the central nervous system (CNS). Activated astrocytes express adhesion molecules, chemokines and release several inflammatory mediators, pro-inflammatory cytokines, neurotrophic and neuroprotective factors, thus these cells have a dual role within the CNS: neuroinflammation and repair processes. IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29 are members of the IL-10 family of cytokines. These cytokines have different biological functions in spite of partial amino acid sequences homology. Signal transduction of the IL-10 family of cytokines is through R1-type and R2-type receptors. Methods: No information has been available about the expression and regulation of IL-19 in mice astrocytes and brain. To investigate the expression of IL-19, we examined its expression in C57BL/6 mice astroglial cells in response to lipopolysaccharide (LPS), using reversetranscription polymerase chain reaction (RT-PCR) method. Results: We provide for the first time, evidence that astrocytes can express IL-19 mRNA following LPS stimulation. Furthermore, we have found the expression of IL-19 mRNA in the cortex of adult C57BL/6 mice following intraperitoneal (i.p.) administration of LPS. Discussion: This finding will contribute to current knowledge on the function and behavior of cells and mediators during inflammatory conditions in the brain
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نویسندگان مقاله بهاره عبد نیک فرجام | bahareh abd nikfarjam
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

معصومه ابتکار | massoumeh ebtekar
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

فرزانه صابونی | farzaneh sabouni
national institutes of genetic engineering and biotechnology, tehran, iran.


زهرا پورپاک | zahra pourpak
immunology, asthma and allergy research institute, tehran university of medical sciences and health services, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم خیراندیش | maryam kheirandish
blood transfusion research center, high institute for research and education in transfusion medicine, tehran, iran.

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-200&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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