این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Basic and Clinical Neuroscience، جلد ۲، شماره ۳، صفحات ۵۱-۵۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of the Flavonoid Quercetin on Pain Sensation in Diabetic Rats
چکیده انگلیسی مقاله Introduction: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. Methods: Rats were divided into control, control or diabetic groups receiving sodium salicylate, untreated diabetic, and quercetin-treated control and diabetic groups. The treatment groups received i.p. administration of quercetin at a dose of 10 mg/kg for 6 weeks. Finally, hyperalgesia were assessed using standard formalin and hot tail immersion tests. Meanwhile, some markers of oxidative stress were also measured in brain tissue.Results: Quercetin or SS treatment of diabetic rats significantly reduced pain score in chronic phase of formalin test (p< 0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p< 0.05) and quercetin treatment of diabetic rats did significantly increase this latency relative to untreated diabetics (p< 0.05). Quercetin treatment of diabetic rats also significantly decreased brain level of malondialdehyde (MDA) (p< 0.05) and nitrite (p< 0.05) and slightly increased activity of superoxide dismutase (SOD) relative to diabetics. Discussion: Taken together, chronic administration of quercetin could attenuate nociceptive score in chronic phase of formalin test in streptozotocin-diabetic rats and could also increase threshold of thermal nociception.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله جمشید نارنجکار | jamshid narenjkar


مهرداد روغنی | mehrdad roghani


هانیه alambeygi | hanieh alambeygi


فرنوش صداقتی | farnoosh sedaghati


نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-64&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات