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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱۲، صفحات ۱۲۳۲-۱۲۳۷
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice
چکیده انگلیسی مقاله Objective(s): Long-term exposure to stress leads to memory deficits and certain mood disorders such as depression and anxiety. We aimed to study the effect of gallic acid (GA) on chronic restraint stress (CRS) induced anxiety and memory deficits in male BALB/c mice.Materials and Methods: Ninety male BALB/c mice were assigned to nine groups including caged control (CC): food-water deprived (FWD), under chronic restraint stress (CRS), CRS+ gallic acid (5, 10, and 20 mg/kg), and gallic acid (5, 10, and 20 mg/kg). Behavioral assays were performed after 21 days of daily treatment with CRS and GA. Serum and brain levels of malondialdehyde (MDA) and total antioxidant capacity (TCA) and serum corticosterone level were also measured. Results: Treatment of CRS mice with GA significantly improved passive avoidance memory in the shuttle box and ameliorated anxiety-like behaviors in the elevated plus maze (EPM) and open filed test (OFT). GA treatment significantly reduced elevated levels of serum and brain MDA and increased brain TCA. CRS and GA did not affect serum corticosterone levels. Treatment of healthy mice with GA had some adverse effects and induced some anxiety and oxidative stress. Conclusion: GA exerted protective effects against stress-induced mood and memory deficit disorders.
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نویسندگان مقاله | Azadeh Salehi
Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran


| Zahra Rabiei
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Mahbubeh Setorki
Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_11676.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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