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Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱۲، صفحات ۱۲۸۹-۱۲۹۶
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عنوان انگلیسی Sleep deprivation disrupts striatal anti-apoptotic responses in 6-hydroxy dopamine-lesioned parkinsonian rats
چکیده انگلیسی مقاله Objective(s): The present study was conducted to examine the effect of sleep deprivation (SD) on the anti-apoptotic pathways in Parkinsonian rats. Materials and Methods: Male Wistar rats (n = 40) were assigned to four groups (10 animals each): sham surgery (Sham), 6-hydroxydopamine (6-OHDA)-lesioned (OH), 6-OHDA-lesioned plus grid control (OH+GC), 6-OHDA-lesioned plus SD (OH+SD). Parkinson's disease (PD) model was induced by the unilateral intra-striatal infusion of 6-OHDA (10 µg/rat). SD (4 hr/day, for 14 days) was induced using a multiple platforms water tank. On the last day of interventions, animals were subjected to open field test for horizontal motor performance assessment. Also, brain-derived neurotrophic factor (BDNF), Bcl-2 and Bax were assessed in the striatum of study groups. Results: SD obscured the motor deficits of PD animals observed in open field test. BDNF level and Bcl2/Bax ratio significantly increased in the OH group, and SD reduced their levels in the PD animals. Conclusion: SD suppressed the anti-apoptotic compensatory responses in the striatum; therefore, it may accelerate continual neuronal cell death in PD.
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نویسندگان مقاله | Nahid Ahmadian
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Molecular Medicine, Faculty of Advanced Biomedical Sciences, Tabriz, Iran


| Javad Mahmoudi
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Mahnaz Talebi
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Leila Molavi
Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran


| saeed Sadigh-Eteghad
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Egill Rostrup
Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark


| Mojtaba Ziaee
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_11706.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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