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Iranian Journal of Pediatric Hematology and Oncology، جلد ۶، شماره ۴، صفحات ۲۲۸-۲۳۴
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عنوان انگلیسی Evaluation of Efficacy of Varicella Vaccine in Pediatric Patients with Acute lymphoblastic Leukemia
چکیده انگلیسی مقاله Abstract Background: Varicella is a highly contagious and dangerous disease especially in immunocompromised patients. Children with cancer are at increased risk of severe illness and may fatal cases occur. Vaccination from VZV ( varicella zoster vaccine) infection can be safe, immunogenic, and effective in children with leukemia who meet the criteria and are at the risk of serious disease or death. The aim of this study was investigate the efficacy of vaccines VZV on pediatric patients with Acute Lymphoblastic Leukemia Materials and Methods: The study was performed on 46 ALL children aged between 1to15 years old who underwent chemotherapy. Considering the efficacy of vaccines on pediatric patients the title serum sample of IgG-anti-VZV avidity was determined using a test kit before and after the injection of vaccines VZV. Results: A total of 46 patients were included analysis. Their title serum sample IgG were negative before the injection of vaccines VZV and after receiving VZV vaccine with respect to title serum sample IgG atatus, 31 (67.4%) patients were positive and 15 (32.6%) patients were negetive. No significant was observed association between either title of IgG-anti-VZV after receiving of VZV vaccine and gender (P = 1.0) title of IgG-anti-VZV and age groups (P =0.387). Conclusion: Regarding the obtained results, it can be concluded that varicella vaccination can have an acceptable effectiveness on pediatric patients with ALL. Varicella vaccination can be recommended for protecting these patients against VZV in order to decrease the morbidity rate caused by this infection. 
کلیدواژه‌های انگلیسی مقاله ALL, children, varicella vaccine
نویسندگان مقاله علی قاسمی | ali ghassemi
associate professor of pediatric hematology oncology, mashhad university of medical sciences, mashhad ,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

زهرا بدیعی | zahra badiee
associate professor of pediatric hematology oncology, mashhad university of medical sciences, mashhad ,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حمید فرهنگی | hamid farhangi
associate professor of pediatric hematology oncology, mashhad university of medical sciences, mashhad ,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عبداله بنی هاشم | abdolah banihashem
professor of pediatric hematology oncology, mashhad university of medical sciences.mashhad,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سید جواد صیدی | seed javad syedi
associate professor of pediatrics, mashhad university of medical science.mashhad,iran


راضیه قدسی | razie ghodsi
biotechnology research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

ابوالقاسم مختاری | abolghassem mokhtari
pediatrician , mashhad university of medical sciences . mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آرمین عطاران زاده | armin attaranzadeh
fellowship cytogentics, mashhad university of medical sciences. mashhad,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-103&slc_lang=en&sid=en
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