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Iranian Journal of Pediatric Hematology and Oncology، جلد ۶، شماره ۴، صفحات ۲۴۸-۲۵۹
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عنوان انگلیسی Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with β- Thalassemia major
چکیده انگلیسی مقاله Abstract Background: Thalassemias are the most common inherited blood disorders caused by some mutations which can reduce the synthesis of globin chains. Iron overload and its organ deposition are responsible for functional abnormalities and tissue injury in patients who affected by β-thalassemia major. The aim of this case-control study was evaluation of hematological parameters, oxidative stress and some serum liver and kidney risk factors which play crucial role for early prediction and prevention of patients to end-stage tissue failure and mortality. Materials and Methods: Present study consisted of Fifty young adult subjects with β-thalassemia major (β- TM) (aged< 18 years) and same number age and sex- matched healthy subjects as control group. Hematological and biochemical laboratory parameters included Urea, Creatinine, Uric Acid, Aspartate Aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP) (pars azmoon kit), oxidative stress biomarker PAB, giving a redox index (chemically), and serum high-sensitivity C-reactive protein (hs-CRP) were evaluated. Results: Urea, Creatinine and Uric Acid were significantly decreased in patients group (P< 0.001); in spite of, serum ferritin, liver biomarkers AST, ALT, ALP and risk factor biomarker PAB were statistically increased in patients versus control group(P< 0.001), whereas hs-CRP(P>0.05) was not significantly difference in study groups. Exception hs-CRP and PAB (P>0.05), liver risk factors had a positive correlation with ferritin and serum Urea, Creatinine and Uric Acid tests had negative meaningful with hematological parameters (P< 0.001). Likewise, PAB with AST showed a positive correlation (P< 0.001) and irreversibly with urea and creatinine (P< 0.001). We did not find a slight correlation between hs-CRP in the company to hematological and biochemical laboratory finding (P>0.05). Conclusion: Higher level of risk factors PAB values and key liver enzyme profiles are able to involve in the prognostic pathological consequences in patients with β-thalassemia major. Even so, they contribute toward the gradual development of tissue injuries.
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نویسندگان مقاله مهرنوش شانکی | mehrnoosh shanaki
department of medical laboratory sciences, school of allied medical sciences, shahid beheshti university of medical scie

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

حسن احترام | hassan ehteram
department of pathology, school of medicine, kashan university of medical sciences, kashan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

هاجر نصیری | hajar nasiri
hematology-oncology and stem cell transplantation research center, tehran university of medical science, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

مهدی آزاد | mehdi azad
department of medical laboratory sciences, faculty of allied medicine, qazvin university of medical sciences, qazvin, i

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

فاطمه کوهکن | fatemeh kouhkan
department of molecular biology and genetic engineering, stem cell technology research center, tehran, iran


ناصر مبرا | naser mobarra
department of epidemiology, faculty of public health, ilam university of medical sciences, ilam, iran7. metabolic disord

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)
سازمان های دیگر: Department of biochemistry, School of Medicine, Golestan University of Medical Sciences, |Gorgan, Iran

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-101&slc_lang=en&sid=en
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