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Iranian Journal of Pediatric Hematology and Oncology، جلد ۶، شماره ۱، صفحات ۹-۱۴
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عنوان انگلیسی Effect of Chewing Gum on Oral Mucositis in Children Undergoing Chemotherapy: A Randomized Controlled Study
چکیده انگلیسی مقاله Background Oral mucositis is an adverse effect of chemotherapy. Type of chemotherapy regimen is the most important factor causing mucositis. Oral mucositis is usually associated with transient decrease in saliva production. The goal was to study effects of gum consumption on oral mucositis in children undergoing chemotherapy. Materials and Methods This randomized controlled trial was done in Amir Kabir Hospital, Arak, Iran. 130 children 5 to 15 years of age were studied. Control group was composed of 65 children who received mucotoxic drugs. Test group was made up of 65 patients received similar drugs in addition to sugar free gums. Patients consumed 6 pieces of gums per day for 15 days. A standardized follow up form and World Health Organization (WHO) grading system for oral mucositis were used for evaluation of patients during 15 days of treatment. Results Severe oral mucositis occurred in 30 (46%) of 65 patients in the test group and in 26 of 65 (40%) patients in the control group. Difference was not statistically significant (P > 0.05). Rate of mild to moderate mucoitis (grade 1 and 2) was significantly lower in patients who used gums (15 % vs. 35%, P < 0.05). Conclusion Our study showed that stimulation of saliva flow by chewing gum could decrease mild to moderate inflammatory injuries of the oral mucosa during chemotherapy. However, it was not effective to subside severe mucositis.
کلیدواژه‌های انگلیسی مقاله Chemotherapy, Children, Gum, Mucositis
نویسندگان مقاله a اقبالی | a eghbali
department of pediatric hematology and oncology, school of medicine, arak university of medical sciences, arak, ran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

b طاهرخانچی | b taherkhanchi
department of pediatrics, school of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

b باقری | b bagheri
cancer research center and department of pharmacology, school of medicine, semnan university of medical sciences, semnan

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

b صادقی سده | b sadeghi sedeh
department of community medicine, school of medicine, arak university of medical sciences, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-68&slc_lang=en&sid=en
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