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Iranian Journal of Pediatric Hematology and Oncology، جلد ۶، شماره ۱، صفحات ۳۲-۳۷
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عنوان انگلیسی Evaluation Efficacy of Ferrous Sulfate Therapy on Headaches of 5-15 Years Old Iron Deficient Children with Migraine
چکیده انگلیسی مقاله Abstract Background Some researches have shown the association between iron deficiency and migraine headache in adults. The aim of present study was to evaluate efficacy of ferrous sulfate treatment on migraine headaches of 5-15 years old migraineur children with iron deficiency. Materials and Methods In a quasi- experimental study, monthly frequency, severity, duration and disability of headaches of 5-15 years old migraineur children that prophylactic therapy was indicated in them and had iron deficiency who were referred to Pediatric eurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran between 2013 and 2015 and were treated with 2mg/kg/day topiramate plus 4mg/kg/day of ferrous sulfate for three consecutive months, were evaluated and headache characteristics before and after treatment were compared. Results In this study, 98 children with mean age of 9.72±3.19 were evaluated that 31children (31.6%) had iron deficiency. Monthly frequency (22.89±7.18 vs.14.5±4.56, P= 0.02), severity score (8.12± 1.76 vs. 5.03±1.15, P= 0.02) and disability score of headache (38.23±10.7vs. 30.12±7.46, P= 0.03) were more in children with iron deficiency. Iron therapy was effective in decreasing of monthlyfrequency 22.89± 7.18 vs. 10.13±4.51, P = 0.001), severity score (8.12±1.76 vs. 5.11±1.62, P =0.001), duration (2.14±1.23 vs.1.14±1.01, P= 0.001) and disability score of headache (38.23±10.7 vs. 22.87±8.65, P= 0.01). Conclusion In children, iron deficiency increased monthly frequency, severity and disability of migraine headache and ferrous sulfate can be used as a safe and effective drug in migraine prophylaxis.
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نویسندگان مقاله r فلاح | r fallah
department of pediatrics, children growth disorders research center, shahid sadoughi university of medical sciences, yaz


s زارع بیدکی | s zare bidoki
department of pediatrics, shahid sadoughi university of medical sciences, yazd , iran.


m اردویی | m ordooei
department of pediatrics, shahid sadoughi university of medical sciences, yazd , iran.
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-71&slc_lang=en&sid=en
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