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Iranian Journal of Pediatric Hematology and Oncology، جلد ۶، شماره ۱، صفحات ۵۲-۶۳
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عنوان انگلیسی Association Between RFC1 G80A Polymorphism and Acute Lymphoblastic Leukemia: a Review and Meta-Analysis of 10 Studies
چکیده انگلیسی مقاله Background Evidence indicates RFC1 G80A polymorphism as a risk factor for a number of cancers. Increasing studies have been conducted on the association of RFC1 G80A polymorphism with acute lymphoblastic leukemia (ALL) risk. However, the results were controversial. The aim of the present study was to derive a more precise estimation of the relationship. Materials and Method PubMed, Embase, Web of Science, Cochrane database, and Google Scholar were searched to get the genetic association studies between RFC1 G80A polymorphism and ALL. All eligible studies for the period up to February 2016 were identified. Subgroup analyses regarding ethnicity were also implemented. All statistical analyses were done with CMA 2.0. Results A total of ten studies comprising of 2,168 ALL cases and 2,693 healthy controls were included in this meta-analysis. Overall, no significant association was detected for allelic model (OR = 1.029, 95 % CI 0.754- 1.405, P=0.000), Dominant model (OR = 1.619, 95 % CI 0.847-3.094, P=0.145), recessive model (OR = 1.169, 95 % CI 10.764-1.790, P=0.429), and homozygote model (OR = 1.288, 95 % CI 0.928-1.788, P=0.130). However, there was an obvious association under the heterozygote model (OR = 1.368, 95 % CI 1.056- 1.772, P=0.018). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of OC was found in the Asian and Caucasian populations. However, there was not significant heterogeneity between heterozygote genetic model (P = 0.15, I2 = 33%) in Caucasian. Therefore, we utilized the fixed-effect model to merge OR value. Conclusion Based on the available evidence, no association between RFC1 G80A Polymorphism and ALL risk was observed, even in the subanalysis by ethnicity. The direction of further research should focus not only on the simple relationship of RFC1 G80A Polymorphism and ALL risk, but also on gene–gene and gene-environment interaction.
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نویسندگان مقاله m فرات یزدی | m forat yazdi
.department of internal medicine, shahid sadoughi university of medical sciences, yazd, iran.


f حسینی بیوکی | f hosseini biouki
department of psychology, shahid sadoughi university of medical sciences, yazd, iran.


j صالحی | j salehi
faculty of pharmacy, shahid sadoughi university of medical sciences, yazd, iran.


h نعمت زاده | h neamatzadeh
.hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran.


r معصومی | r masoumi dehshiri
.hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran. 5.nutrition and fo

سازمان های دیگر: Nutrition and Food Security Research Centre, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

z صدری | z sadri
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran.


f غنی زاده | f ghanizadeh
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran.

سازمان های دیگر: Department of nursing, Yazd Brach, Islamic Azad University, Yazd, Iran

r شیخ پور | r sheikhpour
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran

سازمان های دیگر: Department of nursing, Yazd Brach, Islamic Azad University, Yazd, Iran

h زارع زردینی | h zare zardini
hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran.
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-76&slc_lang=en&sid=en
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