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Iranian Journal of Pediatric Hematology and Oncology، جلد ۵، شماره ۳، صفحات ۱۵۵-۱۶۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The roles of IL-2, IL-7, and IL15 Ligands in B Cells development
چکیده انگلیسی مقاله Abstract Background B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as  -common family have an essential cytokines may support either synergistically or in an additive manner to B cell proliferative activity. Thus, the present study focused specifically on IL2, IL7, and IL15 cytokines that may play a critical role in B cell proliferation in cord blood. In this study, we evaluated the generation of B cells from CD34+/- cord blood mononuclear cells by using IL-2, IL- 7, and IL-15. Material and Methods Cord blood mononuclear cells were cultured for 21 days in presence of different combination of IL-2, IL-7, and IL-15. Harvested cells were analyzed by flow cytometry at days 0, 7, 14 and, 21. Results Present study showed that B cell differentiation from CD34+ cord blood mononuclear cells was increased by using IL-2 and IL-7 at different time points however, IL7 was more effective (P value < 0.0001). In contrast, IL-15 didn’t increase significantly B cell expansion from CD34+ cord blood mononuclear cell. Conclusion These findings showed that IL-2 and IL-7 significantly increased B cell generation from cord blood CD34+ cells probably this cytokines may be used in ex vivo generation of B cells from cord blood mononuclear cells.
کلیدواژه‌های انگلیسی مقاله B cells, CD34+ cells, Cytokine, Umbilical
نویسندگان مقاله z علیاری | z aliyari
stem cell research center, tabriz university of medical sciences, tabriz, iran. 2. student research committee, faculty

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
سازمان های دیگر: Student research committee, Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran

f عالمی | f alami
stem cell research center, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

t مصطفوی | t mostafavi
stem cell research center, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

h طایفی نصرآبادی | h taiefi nasrabadi
tissue engineering research group, novin school of advanced medical school, tabriz university of medical sciences, tabri

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

j سلیمانی راد | j soleimanirad
tissue engineering group, novin school of advanced medical sciences, tabriz university of medical sciences, tabriz, ira

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

h نوزاد | h nozad charoudeh
stem cell research center, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
سازمان های دیگر: Tissue engineering group, Novin School of Advanced Medical Sciences, Tabriz University of Medical Sciences, |Tabriz, Iran.

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-53&slc_lang=en&sid=en
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