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Iranian Journal of Pediatric Hematology and Oncology، جلد ۵، شماره ۱، صفحات ۴۳-۵۱
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عنوان انگلیسی Low Frequency of C-MPL Gene Mutations in Iranian Patients with Philadelphia-Negative Myeloproliferative Disorders
چکیده انگلیسی مقاله Background Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene were described in patients with Philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of present study was to investigate the frequency of c-MPL and JAK2V617F mutations in Iranian patients with Philadelphia-negative myeloproliferative disorders. Material and Methods Peripheral blood samples from 60 patients with Philadelphia-negative MPD) subgroups ET and PMF) and 25 healthy subjects as control were collected in order to investigate the mutation status of c-MPL and Jak2V617F by using Amplification-Refractory Mutation System (ARMS) and Allele-Specific PCR (AS-PCR), respectively and results were confirmed by sequencing. Results Among the total 60 patients studied, 34 (56.6%) and 1(1.7%) had Jak2V617F and c-MPL mutation, respectively. Patients with Jak2V617F mutation had higher WBC counts and hemoglobin concentration than those without the mutation (p= 0.005, p=0.003). In addition for all healthy subjects in control group, mutation was negative. Conclusions The present study revealed that the c-MPL mutations unlike the Jak2V617F mutations were rare in Iranian patients with Ph-negative MPNs and the low mutation rate should be considered in the design of screening strategies of MPD patients.
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نویسندگان مقاله a قوطاسلو | a ghotaslou
ms.c student , department of hematology,school of allied medical sciences , tehran university of medical sciences, tehra

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f نادعلی | f nadali
associate professor, departement of hematology, school of allied medical sciences , tehran university of medical science

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

a قاسمی | a ghasemi


b چهاردولی | b chahardouli
- assistant professor, hematology-oncology and stem cell transplantation research center, tehran university of medical s

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

s عباسیان | s abbasian


s رستمی | s rostami
- assistant professor, hematology-oncology and stem cell transplantation research center, tehran university of medical s

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

n ms c علیزاد قندفروش | n ms c alizad ghandforosh
- ms.c student, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

k علی مقدم | k alimoghaddam
- professor, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, t
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a md قوام زاده | a md ghavamzadeh
- professor, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, t

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-37&slc_lang=en&sid=en
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