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Iranian Journal of Pediatric Hematology and Oncology، جلد ۵، شماره ۱، صفحات ۵۰-۶۴
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عنوان انگلیسی Refractory iron deficiency anemia and Helicobacter Pylori Infection in pediatrics: A review
چکیده انگلیسی مقاله Background Since the discovery of Helicobacter pylori, several clinical reports have demonstrated that H. Pylori infection has emerged as a new cause of refractory iron stores in children. We carried out a systematic literature review to primarily evaluate the existing evidence on the association between childhood H. Pylori infection and iron deficiency anemia (IDA) and secondly, to investigate the beneficial effects of bacterium elimination. Material and Methods This review concerns important pediatric studies published from January 1991 to October 2014. Fourteen case reports and series of cases, 24 observational epidemiologic studies, seven uncontrolled trials, and 16 randomized clinical trials were included in the review. Results Although there are a few observational epidemiologic studies and some randomized trials mostly due to the potential confounders, most studies reported a positive association linking between H. Pylori infection and iron deficiency or iron deficiency anemia among children. In addition, it seems that elimination of H. Pylori infection induces beneficial effects on iron deficiency. Conclusions Since the evidence for the association of H. pylori eradication therapy and refractory childhood IDA is not enough and there are contrasting data about such association, future high quality and cohort researches are needed to determine the causal association.
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نویسندگان مقاله sh غیبی | sh gheibi
associate professor of pediatric gastroenterology, maternal and childhood obesity research center, urmia university of m

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

hr فرخ اسلاملو | hr farrokh eslamlou
.associate professor of maternal and child health, reproductive health research center, urmia university of medical scie

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

m نوروزی | m noroozi
.assistant professor of pediatric hematology and oncology, department of pediatric. urmia university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

a پاک نیت | a pakniyat
emergency medicine resident, department of emergency medicine, arak university of medical sciences , i.r iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-38&slc_lang=en&sid=en
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