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Iranian Journal of Pediatric Hematology and Oncology، جلد ۴، شماره ۲، صفحات ۶۸-۷۱
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عنوان انگلیسی Bone density in transfusion dependent thalassemia patients in Urmia, Iran
چکیده انگلیسی مقاله Background Patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. The mechanism of osteoporosis in these patients is multifactorial. Transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyroidism, hypoparathyroidism, lack of sex steroids and vitamin D deficiency that contribute to impairment in achieving an adequate bone mass .The aim of this study was assessment of frequency of bone loss in patients with thalassemia major and intermedia in Urmia City of West Azerbaijan, Iran Materials and Methods In this cross sectional descriptive study,10 patients (lower than 18 y/o)with transfusion dependent thalassemia attending to Motahari and Emam Khomeini hospitals in Urmia city of Iran were enrolled and scanned for Bone Mineral Density (BMD) starting at around 10 years old. Results Tenatients (6 male and 4 female) with transfusion dependent thalassemia (β-thalassemia major and intermedia) aged 13to 17 years in Urmia city of Iran were enrolled. Mean age of patients was 15.1±.37year old. Among them, 8 patients (80%)had low BMD and2 of them (20%) had normal BMD in lumbar spine. Only 30% of patients had low BMD in the neck of femur. Conclusion We should perform annual BMD in patients with thalassemia major and intermedia and hemoglobin H disease in age of higher than 8 year old and treat low BMD with administration of bisphosphonate, calcium and vitamin D supplements. Medical consultation with a rheumatologist and /or an endocrinologist should be performed in these patients. Changing lifestyle with mild daily exercise, adequate calcium containing foods, avoiding heavy activities, stop smoking, iron chelation therapy in adequate dosage, early diagnosis and treatment of endocrine insufficiency and regular blood transfusions can help to achieve an optimal bone density in these patients.
کلیدواژه‌های انگلیسی مقاله Thalassemia,Bone mineral density, Osteoporosis, Bone Loss
نویسندگان مقاله n ولی زاده | n valizadeh
assistant professor of hematology medical oncology, urmia university of medical sciences, urmia, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

f فرخی | f farrokhi
medical student, urmia university of medical sciences, urmia, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

v علی نژاد | v alinejad
msc. of biostatistics, patient safety research center, urmia university of medical sciences, urmia, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

sm سیدمردانی | sm said mardani
assistant professor of rheumatology, urmia university of medical sciences, urmia, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

n ولی زاده | n valizadeh
assistant professor of endocrinology and metabolism, urmia university of medical sciences, urmia, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)

s حجازی | s hejazi
assistant professor of pediatric hematology medical oncology, department of pediatric hematology, motahari hospital, urm


m نوروزی | m noroozi
assistant professor of pediatric hematology medical oncology, department of pediatric hematology, motahari hospital, urm
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-14&slc_lang=en&sid=en
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