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Iranian Journal of Pediatric Hematology and Oncology، جلد ۳، شماره ۳، صفحات ۹۷-۱۰۲
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عنوان انگلیسی Methylene Blue Based Device for Pathogen Reduction in Human Plasma
چکیده انگلیسی مقاله Abstract Background Despite improvement in safety of plasma transfusion some virus transmission still remains a problem. So as World Health Organization (WHO) recommends, many countries developed Pathogen Reduction Technologies (PRT) to inactivate pathogens, in plasma components. The Methylene Blue (MB) based methods is one of the most universal one. The purpose of this research was, produce a device that can inactivate viruses in MB environment. Materials and Methods In this interventional study, each Plasma Sample was illuminated by 70Pieces (PCs) of 1 w red Light Emitting Diodes (LEDs) from one side. These LEDs emit light at central wavelength of 627 nm with 20 nm Full Width at Half Maximum (FWHM). Two model viruses Herpes Simplex Virus (HSV) and Vesicular Stomatitis Virus (VSV) were used and Tissue Culture 50% Infection Dose (TCID50) was used to calculate virus Log reduction. Two concentration of MB and 5 different illumination times were used. Results In 10 µm concentration of MB, HSV had 6.00±0.2 maximum log reduction that obtain after 60 minutes illumination and VSV had 5.50±0.3 maximum log reduction after 75 minutes illumination. In 1 µM concentration of MB, HSV had 5.20±0.3 maximum log reduction that obtain after 60 minutes illumination and VSV had 4.90±0.2 maximum log reduction after 75 minutes illumination. Conclusion Results of virus inactivation in this method were similar to other methods (P-value< 0.05 in comparison with Spring method, and P-value>0.05 in comparison with Theraflex), and it showed this device could inactivate viruses according to WHO recommendation.
کلیدواژه‌های انگلیسی مقاله Blood-borne Pathogens,Plasma, Methylene Blue
نویسندگان مقاله a الیکایی | a elikaei
1. department of microbiology, faculty of biological science shahid beheshti university, gc, tehran, iran.

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

سید محمد حسینی | s m hosseini
department of microbiology, faculty of biological science shahid beheshti university, gc, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

z شریفی | z sharifi
virology laboratory, research centre of iranian blood transfusion organization ibto , tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

h لطیفی | h latifi
laser and plasma research institute, shahid beheshti university, gc, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

h نیکبخت | h nikbakht
laser and plasma research institute, shahid beheshti university, gc, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

h میرشفیعی | h mirshafiee
virology laboratory, research centre of iranian blood transfusion organization ibto , tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

a اسداللهی | a asadollahi
laser and plasma research institute, shahid beheshti university, gc, tehran, iran

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-90&slc_lang=en&sid=en
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