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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱، شماره ۲، صفحات ۶۷-۷۰
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عنوان انگلیسی Lacunar infarction in child with Protein S deficiency: a case report
چکیده انگلیسی مقاله Abstract Arterial ischemic stroke defines as a new focal neurologic deficit that lasted 24 hours or longer. Stroke is relatively rare in children and incidence of cerebrovascular disease is 1 per 4000 in neonates and 1 per 7000 to 1 per 70000 in older children (1 month to 18 years). Protein S deficiency is one of the causes of the stroke in children. Major manifestations of protein S deficiency are deep venous thrombosis, superficial thrombophlebitis, and pulmonary emboli. The pathogenesis of vascular occlusion in patients with protein S deficiency is unknown. The prevalence of protein S deficiency is between 1% to 7% for first episode of deep venous thrombosis. We present a case of the 6-year-old boy with a history of tonic clonic sizure within a period of 3 years. He subsequently developed acute aphasia and right hemiparesis. Brain magnetic resonance imaging revealed lacunar infarction. Laboratory finding showed that low level of total protein S. The patient was treated with intravenous heparin and patient completely improved. There are no evidence based strategies for the treatment of children with prothrombotic abnormality (because of the lack of research on this subject). How ever this patient completely improved and discharged with oral anticoagulant.
کلیدواژه‌های انگلیسی مقاله Pediatric, protein S deficiency, CVA
نویسندگان مقاله سید علیرضا azarpeikan | sar azarpeikan
shahid sadoughi university of medical sciences and health services, yazd, iran


اعظم سادات هاشمی | azam sadat hashemi
department of pediatrics, hematology, oncology and genetics research center, shahid sadoughi university of medical scien


عاطف عاطفی | atef atefi
hematology, oncology and genetics research center, shahid sadoughi university of medical sciences and health services, y
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-16&slc_lang=en&sid=en
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