این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pediatric Hematology and Oncology، جلد ۱، شماره ۱، صفحات ۴-۷
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عنوان انگلیسی Efficacy of Chicory in Decreasing Serum Ferritin and Liver Enzymes in Major Beta Thalassemia Patients
چکیده انگلیسی مقاله Abstract Objective Thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. The objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. Methods Among 70 beta thalassemia patients, 50 were selected for chelating therapy using inulin of chicory. The initial dose was 1gr given twice a day. Twenty patients were excluded because of Hepatitis B and C and cardiac heart failure. Results From 50 patients, 47 patients tolerated chicory, which the majority showed dramatic responses. Mean serum ferritin level decreased from 3563.09 ng/ml to 1728.54 ng/ml. Mean serum AST level decreased from 25.44 u/lit to 22.25 u/lit. Mean serum ALT level decreased from 30 .861u/lit to 25.085u/iit. Serum ferritin level decreased significantly after treatment (PV≈ 0.00), but there was no significant difference in AST (PV=0.379) and Alt (0.367) after chicory treatment. Conclusion The present results suggest that chicory can reduce iron over load and liver enzymes. Significant differences in serum ferritin were found during intervention, but not in LFT enzymes.
کلیدواژه‌های انگلیسی مقاله Major beta thalassemia, Chicory, Ferritin, Liver enzymes
نویسندگان مقاله نجمه shahvazian | najme shahvazian
general practitioner, yazd, iran


اعظم سادات هاشمی | azam sadat hashemi
department of pediatrics, hematology, oncology and genetics research center, shahid sadoughi university of medical scien


مهرداد شکیبا | mehrdad shakiba
- department of pediatric, shahid sadoughi university of medical sciences and health services, yazd, iran


محمد حسین فرحزادی | mohammad hosein farahzadi
general practitioner, yazd, iran


فاطمه محمودآبادی | fatemeh mahmoodabadi
bsc. farokhi hospital, yazd, iran
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-2&slc_lang=en&sid=en
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