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Iranian Journal of Pediatric Hematology and Oncology، جلد ۱، شماره ۱، صفحات ۱۹-۲۳
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عنوان انگلیسی Frequency of Tumor Lysis Syndrome in Aggressive and Slow Introduction Chemotherapy in Children with ALL
چکیده انگلیسی مقاله Abstract Background Tumor Lysis Syndrome (TLS) is an oncologic emergency that results from massive lysis of malignant cells. The incidence of TLS depends on the risk factors, such as baseline hyperuricemia, bulky tumor burden, elevated serum LDH, and elevated WBC. The objectives of the present study were to assess frequency of Tumor Lysis Syndrom in children with ALL in two methods of induction chemotherapy, aggressive and slow induction. Materials and Methods In this double blind randomized interventional study, the number of 60 ALL patients in the Shahid Sadoughi Hospital Yazd were studied. They randomly treated using two various methods 30 patients by invasive and 30 by slow induction chemotherapy. Results From 60 patients, 10 cases (16.6%) developed Tumor lysis syndrome. Seven of 10 treated by aggressive chemotherapy and remaining 3 by slow chemotherapy. No significant differences were found (PV= 0.166) between them. Conclusion Based on this study there was no significant difference between Tumor Lysis Syndrom in aggressive induction chemotherapy and slow induction, but WBC and LDH levels before treatment can predict Tumor Lysis Syndrom.
کلیدواژه‌های انگلیسی مقاله ALL, Tumor Lysis Syndrome, Induction Chemotherapy
نویسندگان مقاله اعظم سادات هاشمی | azam sadat hashemi
department of pediatrics, hematology, oncology and genetics research center, shahid sadoughi university of medical scien


نجمه shahvazian | najme shahvazian
general practitioner , yazd, iran


اصغر زارع زاده | asghar zarezade
general practitioner , yazd, iran


مهرداد شکیبا | mehrdad shakiba
department of pediatrics, shahid sadoughi university of medical sciences and health services, yazd, iran


عاطف عاطفی | atef atefi
hematology, oncology and genetics research center, shahid sadoughi university of medical sciences and health services, y
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-5&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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