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Journal of Research in Medical Sciences، جلد ۲۱، شماره ۸، صفحات ۰-۰
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عنوان انگلیسی The effect of combined conventional and modified ultrafiltration on mechanical ventilation and hemodynamic changes in congenital heart surgery
چکیده انگلیسی مقاله Background: Cardiopulmonary bypass is associated with increased fluid accumulation around the heart which influences pulmonary and cardiac diastolic function. The aim of this study was to compare the effects of modified ultrafiltration (MUF) versus conventional ultrafiltration (CUF) on duration of mechanical ventilation and hemodynamic status in children undergoing congenital heart surgery.Materials and Methods: A randomized clinical trial was conducted on 46 pediatric patients undergoing cardiopulmonary bypass throughout their congenital heart surgery. Arteriovenous MUF plus CUF was performed in 23 patients (intervention group) and sole CUF was performed for other 23 patients (control group). In MUF group, arterial cannula was linked to the filter inlet through the arterial line, and for 10 min, 10 ml/kg/min of blood was filtered and returned via cardioplegia line to the right atrium. Different parameters including hemodynamic variables, length of mechanical ventilation, Intensive Care Unit (ICU) stay, and inotrope requirement were compared between the two groups. Results: At immediate post?MUF phase, there was a statistically significant increase in the mean arterial pressure, systolic blood pressure, and diastolic blood pressure (P < 0.05) only in the study group. Furthermore, there was a significant difference in time of mechanical ventilation (P = 0.004) and ICU stay (P = 0.007) between the two groups. Inotropes including milrinone (P = 0.04), epinephrine (P = 0.001), and dobutamine (P = 0.002) were used significantly less frequently for patients in the intervention than the control group. Conclusion: Administration of MUF following surgery improves hemodynamic status of patients and also significantly decreases the duration of mechanical ventilation and inotrope requirement within 48 h after surgery.
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نویسندگان مقاله محسن ضیایی فرد | mohsen ziyaeifard


آذین alizadehasl | azin alizadehasl


ناهید عقدایی | nahid aghdaii


پوپک رحیم زاده | poupak rahimzadeh


غلامرضا معصومی | gholamreza masoumi


صمد ej گلزاری | samad ej golzari


مصطفی فتاحی | mostafa fatahi


فرهاد gorjipur | farhad gorjipur


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10537
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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