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Journal of Research in Medical Sciences، جلد ۲۱، شماره ۸، صفحات ۰-۰
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عنوان انگلیسی Relationship between clopidogrel-related polymorphisms and variable platelet reactivity at 1 year: A cohort study from Han Chinese
چکیده انگلیسی مقاله Background: This study was designed to investigate the eff ect of clopidogrel-related gene polymorphisms on platelet reactivity and clinical outcome in Chinese Han patients. Materials and Methods: Th ree hundred and thirty-six percutaneous coronary intervention - treated patients were recruited and followed for 1 year. Blood samples were collected from all patients for DNA genotyping. Th e platelet reactivity unit was measured by the VerifyNow technique. Th e CYP2C19*2, CYP2C19*3, CYP2C19*17,ATP-binding cassette subfamily B member 1, ITGB3, CYP2C9*3, CYP2B6*9, and P2Y12 alleles were assessed. Results: Th e clinical endpoints were related to previous heart disease history (11.90% vs. 28.57%, P = 0.017), stroke (12.24% vs. 16.67%, P = 0.039), and diabetes (27.55% vs. 52.38%, P = 0.047). High on-treatment platelet reactivity (HTPR) was frequent in advanced age (P = 0.019), male gender (P = 0.016), hypertension (P = 0.033), and chronic renal failure (P = 0.040). Th ere were more endpoints in the CYP2C19*2 and P2Y12 mutant carriers (76.19% vs. 43.20%, P < 0.001; 50.00% vs. 35.71%, P = 0.001, respectively), whereas fewer in the CYP2C19*17 mutant carriers (11.90% vs. 56.46%, P = 0.001). CYP2C19*2 and P2Y12 polymorphism manifested HTPR (194.25 ± 45.91 vs.151.38 ± 58.14, P < 0.001; 180.33 ± 67.25 vs. 161.89 ± 56.49, P = 0.008, respectively), whereas CYP2C19*17 mutant improved platelet reactivity (97.17 ± 45.38 vs. 169.08 ± 57.15, P = 0.003). However, there were no further cardiovascular deaths in endpoint patients.Conclusion: In Han Chinese people of mainland China, clopidogrel-related gene polymorphisms are related to variable platelet reactivity after clopidogrel maintenance dosing, which infl uences major adverse cardiovascular events, without an eff ect on cardiac death.
کلیدواژه‌های انگلیسی مقاله Clopidogrel, polymorphism, VerifyNow
نویسندگان مقاله xiaodong ونگ | xiaodong wang


یان حسین پور | yan lai


yu luo | yu luo


xumin زانگ | xumin zhang


hua zhou | hua zhou


zi ye | zi ye


ژیانی تنگ | jiani tang


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10540
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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