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Journal of Research in Medical Sciences، جلد ۲۰، شماره ۱، صفحات ۰-۰
عنوان فارسی
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عنوان انگلیسی Does Vitamin C improve endothelial function in patients with Kawasaki disease?
چکیده انگلیسی مقاله Background: Improvement of endothelial dysfunction could prevent or delay the occurrence of the atherosclerosis process in patients with Kawasaki disease (KD). It is suggested that Vitamin C could improve endothelial dysfunction. In this study, we investigated whether administration of Vitamin C as a water-soluble antioxidant could be effective in this regard among patients with KD. Materials and Methods: In this case control analytic-experimental study, children aged 3-18 years with KD, and a group of healthy children evaluated. Vitamin C (250 mg/daily) administrated for the two studied groups for 1 month. Endothelial function evaluated by flowmediated dilatation (FMD) and intima-media thickness (IMT) measurement using vascular Doppler ultrasonography, before and after trial. Results: In this study, 16 patients with KD and 19 normal children were studied. At baseline mean of IMT and FMD was not different in the two studied groups ( P > 0.05). After Vitamin C administration IMT decreased significantly in two studied groups (from 27.06 ± 6.27 to 21.56 ± 3.77 in KD group and from 27.66 ± 5.66 to 23.33 ± 3.66 in control group [ P < 0.05]). FMD increased in two studied groups, but the difference was significant in the control group (from 6.84 ± 2.51 to 7.03 ± 2.87 in KD group and from 6.53 ± 2.36 to 7.82 ± 2.14 in the control group). Conclusion: Vitamin C might improve the endothelial function of patients with KD.
کلیدواژه‌های انگلیسی مقاله Endothelium, Kawasaki disease, Vitamin C
نویسندگان مقاله محمد رضا صبری | mohammad reza sabri


اسفندیار نجفی توانا | esfandiar najafi tavana


علیرضا احمدی | alireza ahmadi


ناصر mostafavy | naser mostafavy


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/10129
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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