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Journal of Research in Medical Sciences، جلد ۲۰۱۴، شماره ۰۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Repeated Transsphenoidal Surgery or Gamma Knife Radiosurgery in Recurrent Cushing Disease after Transsphenoidal Surgery
چکیده انگلیسی مقاله Background: This study compared Gamma knife radiosurgery (GKRS) and repeated transsphenoidal adenomectomy (TSA) to find the best approach for recurrence of Cushing disease (CD) after unsuccessful first TSA. Materials and Methods: Fifty-two patients with relapse of CD after TSA were enrolled and randomly underwent a second surgery or GKRS as the next therapeutic approach. They were followed for a mean period of 3.05 ± 0.8 years by physical examination and hormone measurement as well as magnetic resonance imaging. Results: No significant difference was observed in sex ratio, mean age, adenoma type, follow-up duration, and initial hormone level between the two groups. No significant relationship was found between preoperative 24-hour free urine cortisol and disease-free months or tumor volume among both groups. Our statistical analysis showed higher recurrence-free interval in the GKRS group compared with TSA group. Conclusion: With longer recurrence-free interval, GKRS could be considered a good treatment alternative to repeated TSA in recurrent CD. Normal 0 false false false EN-US X-NONE AR-SA
کلیدواژه‌های انگلیسی مقاله Cushing syndrome,Gamma knife,Transsphenoidal Surgery
نویسندگان مقاله محمد علی بیطرف | mohammad ali bitaraf
department of neurosurgery, kasra hospital, tehran univeristy of medical sciences


محمد بداغ آبادی | mohammad badaghabadi
department of neurosurgery, kasra hospital, tehran univeristy of medical sciences


حسین ریاضی | hossein riazi
department of neurosurgery, kasra hospital, tehran univeristy of medical sciences


مزدک علیخانی | mazdak alikhani
department of neurosurgery, kasra hospital, tehran univeristy of medical sciences


مازیار آذر | mazyar azar
department of neurosurgery, kasra hospital, tehran univeristy of medical sciences
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9691
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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