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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Anti-ribosomal Pantibodies related to depression in early clinical course of systemic lupus erythematosus
چکیده انگلیسی مقاله Background: Diagnosis and treatment of neuropsychiatric lupus is still a major challenge in clinical practice. We investigated the association between depression and anti-ribosomal P (anti-P) antibodies in a sample of Iranian patients with systemic lupus erythematosus (SLE). Materials and Methods: Th is cross-sectional study was conducted on adult patients with SLE referring to a referral out-patient clinic of rheumatology. Demographic data and clinical data with regards to measuring disease activity with the systemic lupus erythematosus disease activity index were gathered. Anti-P antibodies were measured with the enzyme-linked immunosorbent assay method. Depression severity was measured by the Beck Depression Inventory-II. Results: One hundred patients (80% female and 20% male, age = 34.8 ± 10.9 years) were included. Anti-P antibodies were present more frequently in depressed than non-depressed patients (30% vs. 10%, P = 0.015). Depression severity was correlated with anti-P antibodies level only in patients with disease duration of less than 2 years (r = 0.517, P = 0.019). Th ere was no association between the depression severity and disease activity. Binary logistic regression analysis showed age (B = 0.953, CI 95%: 0.914-0.993) and positive anti-P antibodies (B = 4.30, CI 95%: 1.18-15.59) as factors that independently associated with depression. Conclusion: We found an association between depression and presence of anti-P antibodies, and also strong correlation between depression severity and anti-P antibodies level in newly diagnosed SLE patients. Depression severity in newly diagnosed SLE patients may refl ect a neuropsychiatric involvement,and in later phases, it is more aff ected by the chronicity of the disease as well as other environmental factors.
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نویسندگان مقاله منصور کریمی فر | mansoor karimifar


ایمان شریفی | iman sharifi


کتایون شفیعی | katayoun shafiey


نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/9539
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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