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Journal of Research in Medical Sciences، جلد ۱۸، شماره ۱، صفحات ۴۴-۰
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عنوان انگلیسی Association of serum uric acid with proteinuria in type 2 diabetic patients
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA Background: Various findings suggest that uric acid is an inflammatory factor and may have a role in endothelial dysfunction and act as a mediator of diabetic nephropathy. The objective of this study was to evaluate the relationships between serum uric acid level and level of proteinuria in type 2 diabetic (T2D) patients. Methods: A cross-sectional analytical study was conducted in 60 patients with T2D without a history of gout. None was treated with allopurinol. Venous blood samples were obtained in fasting state for determinations of serum creatinine, uric acid, and hemoglobin A 1c (HbA 1c ) (reference range 3.8–5.5%); 24-h urine proteinuria was also measured. Results: Mean age of the patients was 57 ± 8.3 years. Mean ± standard error (SE) of serum creatinine was 0.98 ± 0.028 mg/dL, mean ± SE of serum uric acid was 4.5 ± 0.15 mg/dL, and mean ± SE of proteinuria was 388 ± 28.7 mg/day (median = 303.5 mg/day). There was no significant difference in serum uric acid, HbA 1c , and creatinine level between males and females ( P > 0.05). There was a significant positive association between body mass index (BMI) and serum uric acid levels ( r = 0.428, P = 0.001). After adjustment for weight, a significant positive association of serum uric acid with level of proteinuria was seen ( r = 0.47, P < 0.001). Conclusion: Serum uric acid had a significant positive association with diabetic nephropathy. It might be hypothesized that serum uric acid plays a role in diabetic nephropathy in T2D.
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نویسندگان مقاله سعید بهرادمنش | saeed behradmanesh
medical plants research center, shahrekord university of medical sciences, shahrekord, iran


محمد کرمی هرستانی | mohammad karami horestani
department of internal medicine, shahrekord university of medical sciences, shahrekord, iran


آذر برادران | azar baradaran
department of internal medicine, shahrekord university of medical sciences, shahrekord, iran


حمید نصری | hamid nasri
isfahan kidney disease research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8895
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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