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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی Regulatory T-cell profile in early and late lesions of cutaneous leishmaniasis due to Leishmania major
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Context: Cutaneous leishmaniasis (CL) is a public health problem in several endemic countries. Recent studies on mouse model and also a few clinical experiments showed that the type of immune response generated at the site of infection and especially balance between regulatory and effector T-cells determines the outcome of the disease toward self-limiting or long-lasting lesions. Aims: The aim of this study was to evaluate the role of natural regulatory T cells (nTregs) in early and late cutaneous lesions of human Leishmania major ( L. major ) infection. Settings and Design: Skin biopsies were collected from parasitologically proven lesions of 28 CL patients, divided into two groups of early and late lesions. The causative agents were identified to be L. major . Materials and Methods: Quantitative real-time reverse transcription polymerase chain reaction (PCR)AU: Please define PCR and PBMC at first occurrence. and immunofluorescent staining of biopsies were used to assess the Foxp3 mRNA expression and frequency of nTregs in two groups. Mann-Whitney U test was used to determine the significance of deference between the two groups. Results: Mean relative expressions of Foxp3 mRNA were 0.53  } 0.23 and 1.26  } 0.99 in early and late lesions, respectively, which was significantly upper in chronic lesions ( P = 0.007). Parallel results were obtained in tissue staining method. Conclusions: Increased in gene expression and protein staining of nTreg markers in chronic biopsy samples indicates a role for these cells in chronic L. major induced leishmaniasis and supports the effectiveness of regulatory T cell-based immunotherapy for treatment of chronic CL.
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نویسندگان مقاله شروین g حسینی | shervin g hoseini
department of parasitology and mycology, skin diseases and leishmaniasis research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شقایق حق جو jvanmard | shaghayegh haghjoo jvanmard
department of physiology, physiology research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

سید h زرکش | sayyed h zarkesh
department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی خامسی پور | ali khamesipour
center for research in skin disease and leprosy, tehran, iran


لاله رفیعی | laleh rafiei
department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

خدیجه کربلایی | khadijeh karbalaie
department of cell and molecular biology, cell science research center, royan institute for animal biotechnology, acecr, isfahan

سازمان اصلی تایید شده: پژوهشگاه رویان (Royan institute)

محمدعلی نیلفروش زاده | mohamadali nilforoushzade
skin and stem cell research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهدی بقایی | mehdi baghaei
department of biology, faculty of basic sciences, islamic azad university shahrekord branch, shrekord, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

سید h حجازی | seyed h hejazi
department of parasitology and mycology, skin diseases and leishmaniasis research center, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8483
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زبان مقاله منتشر شده en
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