این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Journal of Research in Medical Sciences، جلد ۱۷، شماره ۱، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of dexmedetomidine on hemodynamic response to tracheal intubation in hypertensive patients: A comparison with esmolol and sufentanyl
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE FA MicrosoftInternetExplorer4 BACKGROUND : Hypertension and tachycardia caused by tracheal intubation can be detrimental in hypertensive patients. This study was conducted in order to compare the effects of dexmedetomidine on hemodynamic response to tracheal intubation in hypertensive patients with esmolol and sufentanyl. METHODS : Sixty hypertensive patients scheduled for noncardiac surgery under general anesthesia were randomly assigned to receive one of the three drugs before induction of anesthesia. Groups I, II, and III respectively received esmolol (100 mg) dexmedetomidine (1 μg/kg) and sufentanyl (0.25 μg/kg). Heart Rate (HR), systolic (SAP) and diastolic (DAP) arterial pressures were recorded before drug administration (baseline; T1), after drug administration (T2), after induction of anesthesia (T3), immediately after intubation (T4) and 3, 5 and 10 minutes after intubation (T5, T6, and T7, respectively). The mean percentage variations from T1 to T4 were calculated for all variables (HR, SAP and DAP). Thiopental dose, onset time of vecuronium and intubation time were also assessed. RESULTS : No differences were observed between the three groups regarding demographic data (p > 0.05). Median thiopental dose was significantly lower in Group II (325 mg; range: 250-500) compared to Group I (425 mg; range: 325-500; p < 0.01) and Group III (375 mg; range: 275-500; p = 0.02). The onset time of vecuronium was longest in Group I (245.2 ± 63 s vs. 193.9 ± 46.6 s and 205.5 ± 43.5 s; p < 0.01 and p < 0.05). In Group I, HR significantly decreased after drug administration compared to baseline (83.8 ± 20.4 vs. 71.7 ± 14.8; p = 0.002). Compared to the baseline (90.4 ± 8.4), DAP decreased after induction and remained below baseline values at T5, T6 and T7 (71.3 ± 12.8, 76.2 ± 10.7, 68.9 ± 10.8 and 62.1 ± 8.7, respectively; p < 0.05) in Group II. According to the mean percentage variation, a significant reduction in HR was assessed in Group II compared to Group III (-13.4 ± 17.6% vs. 11.0 ± 27.8%; p = 0.003). Increment in SAP was significant in Group I when compared to Group II (9.8 ± 20.9% vs. -9.2 ± 20.2%; p < 0.05). Increment in DAP in Group III was significant compared to Group II (0.07 ± 19.8 vs. 24.5 ± 39.1; p < 0.05). CONCLUSIONS : In hypertensive patients, administration of dexmedetomidine before anesthesia induction blunts the hemodynamic response to tracheal intubation and reduces the thiopental dose. KEYWORDS : Hypertension, Tracheal Intubation, Dexmedetomidine, Esmolol, Sufentanyl, Anesthesia
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله هاله yarkan uysal | hale yarkan uysal
specialist, anesthesiology and reanimation clinic, ankara training and research hospital, the ministry of health, ankara, turkey


اسماعیل tezer | esma tezer
specialist, anesthesiology and reanimation clinic, ankara training and research hospital, the ministry of health, ankara, turkey


muge turkoglu | muge turkoglu
resident, anesthesiology and reanimation clinic, ankara training and research hospital, the ministry of health, ankara, turkey


pä±nar aslanargun | pä±nar aslanargun
resident, anesthesiology and reanimation clinic, ankara training and research hospital, the ministry of health, ankara, turkey


hulya basar | hulya basar
associate professor, anesthesiology and reanimation clinic, ankara training and research hospital, the ministry of health, ankara, turkey
نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/7289
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات