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Journal of Research in Medical Sciences، جلد ۱۲، شماره ۴، صفحات ۱۹۰-۰
عنوان فارسی
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عنوان انگلیسی Effect of matricaria recutita on acute pain in the presence and absence of sex hormones
چکیده انگلیسی مقاله BACKGROUND : Chamomile is a beneficial herbal drug that is used as an anti-inflammatory, sedative and anti-allergic agent. The mechanism of action of matricaria recutita (MR), a specious of chamomile, in nociception in male and female animals is not fully understood. In this study, the sedative effect of a species of chamomile, MR, on acute pain was investigated in both male and female adult mice in the presence and absence of sex hormones. METHODS : Male and female NMRI mice weighing 28 ± 3 grams were used. Animals of each sex were divided into intact and gonadectomized groups. Intact group received saline or MR extract (10, 30, 50 mg/kg, intraperitoneally). Gonadectomized group contained two subgroups: a) group that received saline or MR hydro alcoholic extract (50 mg/kg, I.P.), and b) group that received sex hormones (testosterone in male mice and estradiol benzoate and progesterone in female mice), both with and without MR extract (50mg/kg, IP). The analgesia times in all groups were evaluated by hot plate test. RESULTS : MR increased analgesia time both in intact and gonadectomized male and female mice, but had no effect in the presence of pharmacological doses of testosterone (2 mg/kg, subcutaneous) in male mice, and estradiol benzoate (0.1 mg/kg, SC) and progesterone (0.5 mg/kg, SC) in female mice. CONCLUSIONS : It seems that MR can induce a pain-relieving effect with and without physiological doses of sex hormones in male and female mice, but sex hormones probably interact with its analgesic effect in their pharmacological doses. KEY WORDS : Matricaria recutita, pain, testosterone, estradiol benzoate, progesterone, hot plate.
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نویسندگان مقاله مهناز کسمتی | mahnaz kesmati
department of biology, shahid chamran university of ahvaz, ahvaz

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

ندا barfinejad | neda barfinejad
department of biology, shahid chamran university of ahvaz, ahvaz

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

هادی فتحی مقدم | hadi fathi moghadam
department of physiology, ahvaz jundishapur university of medical sciences, ahvaz

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/525
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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