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Avicenna Journal of Phytomedicine، جلد ۴، شماره ۴، صفحات ۲۸۷-۲۹۶
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عنوان انگلیسی Evaluation of analgesic, anti-inflammatory and CNS depressant activities of methanolic extract of Lawsonia inermis barks in mice
چکیده انگلیسی مقاله Objectives: The study was carried out to assess the analgesic, anti-inflammatory, and CNS depressant activity of the methanolic extract of the Lawsonia inermis barks(MELIB). Materials and Methods: Anti-inflammatory effects of MEBLI were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. Analgesic activity was measured using acetic acid-induced writhing model and formalin-induced licking and biting in mice. The CNS depressant activity was evaluated by observing the reduction of locomotor and exploratory activities in the open field and hole cross tests at a dose of 300 and 500 mg/kg body weight. Results: Statistical analysis showed that dose of 500 mg/kg exhibited higher analgesic activity against acetic acid-induced pain in mice than the standard drug diclofenac sodium. Furthermore, doses of 300 and 500 mg/kg caused higher percent of protection (91.16% and 95.03%, respectively) of licking and biting of formalin-induced mice than diclophenac sodium (70.72%). The Lawsonia inemis methanolic extract (300 and 500 mg/kg) alsoexhibited sustained inhibition (54.97% and 65.56%) of paw edema at the 4th hour compared with standard indomethacin (74.17%). Besides, the plant extract also had significant (p< 0.05) dose-dependent CNS depressant activity. Conclusion: this study recommends that the methanolic extract of Lawsonia inermis barks has significant analgesic, anti-inflammatory, and CNS depressant properties.
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نویسندگان مقاله luthfun نسا | luthfun nesa
department of pharmacy, atish dipankar university of science and technology, dhaka, bangladesh


shirajum munira | shirajum munira
department of pharmacy, atish dipankar university of science and technology, dhaka, bangladesh


شبنم mollika | shabnam mollika
department of pharmacy, atish dipankar university of science and technology, dhaka, bangladesh


md monirul اسلام | md monirul islam
department of pharmacy, atish dipankar university of science and technology, dhaka, bangladesh


حبیب الله choin | habibullah choin
department of pharmacy, atish dipankar university of science and technology, dhaka, bangladesh


aktar uzzaman chouduri | aktar uzzaman chouduri
department of pharmacy, university of rajshahi, bangladesh


nazmun naher | nazmun naher
radiant pharmaceutical ltd, tongi, bangladesh
نشانی اینترنتی http://ajp.mums.ac.ir/article_2347.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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