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Avicenna Journal of Phytomedicine، جلد ۳، شماره ۳، صفحات ۲۰۱-۲۰۴
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عنوان انگلیسی Simulation of metabolism-based herb-drug interaction: towards safe and efficacious use of NIPRD-AM1
چکیده انگلیسی مقاله Objective: To evaluate the effect of NIPRD-AM1 on CYP3A4 in order to generate clinically significant data for its safe and efficacious use. Materials and Methods: NIPRD-AM1 is a phytomedicine developed from aqueous root extracts of Nauclea latifolia Smith (Rubiaceae) for the treatment of uncomplicated malaria. The effect of NIPRD-AM1 on CYP3A4 was measured with and without the addition of NIPRD-AM1, by testing different concentrations of the product at 37 °C in reactive mixtures with ketoconazole (2.5 µM) as the positive control. Results: Results showed a very low IC50 value of 0.01 mg/ml similar to that of ketoconazole (0.016 mg/ml). Conclusion: Metabolic processes of NIPRD-AM1 are likely to inhibit CYP3A4, with potential implication on drugs that are CYP3A4 substrates. This is a promising approach for guidance towards the safe and efficacious use of NIPRD-AM1.
کلیدواژه‌های انگلیسی مقاله CYP3A4, Herb-Drug Interactions, Nauclea latifolia, NIPRD-AM1
نویسندگان مقاله bulus adzu | bulus adzu
department of pharmacology and toxicology, national institute for pharmaceutical research and development, pmb 21, abuja, nigeria


kudirat bola مصطفی | kudirat bola mustapha
department of medicinal chemistry and quality control, national institute for pharmaceutical research and development, pmb 21, abuja, nigeria


collen masimirembwa | collen masimirembwa
african institute of biomedical science and technology aibst , cnr chinhoyi str. jason moyo ave. no. 9 at lapf centre, harare, zimbabwe


obiageri obodozie | obiageri obodozie
department of medicinal chemistry and quality control, national institute for pharmaceutical research and development, pmb 21, abuja, nigeria


rukaiyatu عبداللهی kirim | rukaiyatu abdullahi kirim
department of medicinal chemistry and quality control, national institute for pharmaceutical research and development, pmb 21, abuja, nigeria


karniyus shingu gamaniel | karniyus shingu gamaniel
director general chief executive officer, national institute for pharmaceutical research and development, pmb 21, abuja, nigeria
نشانی اینترنتی http://ajp.mums.ac.ir/article_233.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short communication
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