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Avicenna Journal of Phytomedicine، جلد ۱، شماره ۱، صفحات ۱-۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Analgesic effect of clove essential oil in mice
چکیده انگلیسی مقاله Objective: Results obtained from literature reviews and human studies have shown the analgesic effects of clove plant in toothache. The present work was undertaken in order to investigate the possible analgesic effect of clove oil in mice. Materials and Methods: Fifty mice were divided into 5 groups: 1) Saline; 2) Essential oil (Ess) 2%, 3) Ess 5%, 4) Ess10% and 5) Ess 20%. The hot plate test (55±0.2 °C; Cut-off 60 sec) was performed as a base record 15 min before injection of drugs (Saline or 2, 5, 10 and 20% concentrations of Essential oil) and consequently repeated every 15 minutes after injection. Results: Repeated measures ANOVA test showed that maximal percent effect (MPE) in animal groups treated by 5, 10 and 20% essential oil was significantly higher than saline group. Comparison between 4 treated groups showed that MPE in 10% essential group was higher than 2 and 5% groups however; there was no significant difference between 10% and 20% groups. Conclusion: The result of present study showed that clove essential oil has analgesic effect inmice using hot plate test. More investigations are needed to elucidate the exact mechanism (s).
کلیدواژه‌های انگلیسی مقاله Clove, Essential oil, analgesia, Mice, Hot plate
نویسندگان مقاله محمود حسینی | mahmoud hosseini
neuroscience research center and department of physiology, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مینا کامکار اصل | mina kamkar asl
neuroscience research center and department of physiology, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسن رخشنده | hassan rakhshandeh
pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ajp.mums.ac.ir/article_114.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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