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Medical Journal of Islamic Republic of Iran، جلد ۱۵، شماره ۱، صفحات ۳۷-۴۰
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عنوان انگلیسی LEVELS OF ANTI-STREP TOKINASE AND ANTI-MYCOBACTERIAL HEAT SHOCK PROTEIN 65 KILODALTON (ANTI-MHSP 65) ANTIBODIES IN PATIENTS WITH AUTOIMMUNE DISEASES
چکیده انگلیسی مقاله Bacterial and viral triggers are suspected agents in the initial etiology of autoimmune diseases. There are some studies on the etiology of autoimmune disorders which have focused on streptococcal infection and a possible relation with microbial heat shock proteins (hsp) which show significant homology with human heat shock proteins. In addition, some serotypes of streptococci cross-react with human hsp, namely 65kD hsp. Therefore, we have examined isotype specific antibody responses to streptokinase, the antigen released during infection with the common bacterium streptococcus, together with IgG responses to mycobacterium heat shock protein 65 (mhsp 65), a possible superantigen for autoimmune diseases. The levels of these antibodies were examined in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), thyroiditis and Henoch Schonlein purpura (HSP) and a group of normal controls. Patients with RA showed a statistically significant elevation in levels oflgM anti-streptokinase antibodies compared to the control group (p< 0.001). In Henoch Schonlein purpura patients, the levels of lgG and neutralising anti-streptokinase antibodies correlated with the levels of IgG anti-mhsp 65 (r= 0.56, p< 0.09 and r= 0.57, p< 0.08, respectively). According to these findings, we suggest that streptococcal infections may have an important role in the pathogenesis of rheumatoid arthritis and Henoch Schonlein purpura.
کلیدواژه‌های انگلیسی مقاله Streptokinase, Heat shock protein (hsp), autoimmune.
نویسندگان مقاله a افشاری | a afshari
from the department of pathobiology, section of immunology, qazvin university of medical sciences amp; health services, qazvin, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

d burnie | d burnie
the departments of cardiology and immunology, western infirmary, glasgow, u.k.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

er هلم | er holme
the departments of cardiology and immunology, western infirmary, glasgow, u.k.

سازمان اصلی تایید شده: 0 دانشگاه های خارج از کشور

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-277&slc_lang=en&sid=en
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