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International Journal of Molecular and Cellular Medicine، جلد ۳، شماره ۴، صفحات ۲۳۷-۲۴۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی A highly pure sub-fraction of shallot extract with potent in vitro anti-angiogenic activity
چکیده انگلیسی مقاله Abstract Our previous studies showed that various extracts of Persian shallot (Allium hirtifolium) have anti-angiogenic effects. This study has been undertaken to isolate and identify the major effective anti-angiogeneic sub-fraction of shallot. After preparation of the 50% hydroalcoholic extract of shallot bulbs, the extract was successively fractionated into n-hexane, ethyl acetate, n-butanol and aqueous fractions. Anti-angiogenesis activity of fractions was examined by in vitro angiogenesis assay. The ethyl acetate fraction which had the most anti-angiogenesis activity was further fractionated to four sub-fractions by thin layer chromatography (TLC), silica gel column chromatography and then analyzed by High Performance TLC (HPTLC) with ethyl acetate-methanol-water as the solvent system. Our results showed that one of the four sub-fractions, as the major band in HPTLC, had the most anti-angiogenic activity. Purification and characterization of the major anti-angiogenic compound/compounds of shallot's extract may constitute one means by which diets rich in shallot confer protection against cancer and finally introduce new agents with pharmacological activities in shallot as a potential candidate in cancer therapy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله شیما فامیل سماواتی | shima famil samavati
department of biology, islamic azad university, science and research branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

حمیدرضا محمدی مطلق | hamid reza mohammadi motlagh
medical biology research center, kermanshah university of medical sciences, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

علی مصطفایی | ali mostafaie
medical biology research center, kermanshah university of medical sciences, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://www.ijmcmed.org/browse.php?a_code=A-10-260-1&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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