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Medical Journal of Islamic Republic of Iran، جلد ۱۵، شماره ۱، صفحات ۷-۹
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عنوان انگلیسی ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
چکیده انگلیسی مقاله Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared with dizygotic twin concordance, many implicate genetic factors in the development and regulation of the immune responses, such as the HLA class II genes, as candidates for conferring the genetic susceptibility. We studied the distribution of HLADR and DQ antigens and duration of sickness in 42 Iranian patients suffering from DC using the standard microlymphocytotoxicity technique. The phenotypic frequencies ofHLA-DR2 were present in 24 of 84 controls and 18 of 42 patients (p= 0.24, corrected p, not significant). The present study reveals no association between HLA class II antigens and UC, suggesting that the HLA-DR2 is not a predominant susceptibility gene for UC in the population studied.
کلیدواژه‌های انگلیسی مقاله Ulcerative colitis, HLA phenotyping
نویسندگان مقاله h فروتن | h forootan
from the departments of internal medicine and immunogenetics, school of medicine, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b نیک بین | b nikbin
the department of immunology, school of medicine, birjand university of medical sciences, birjand, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

gh عنانی سراب | gh anani sarab
from the departments of internal medicine and immunogenetics, school of medicine, tehran university of medical sciences, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بیرجند (Birjand university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-271&slc_lang=en&sid=en
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