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Medical Journal of Islamic Republic of Iran، جلد ۱۴، شماره ۳، صفحات ۲۹۷-۳۰۱
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عنوان انگلیسی EFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS
چکیده انگلیسی مقاله Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was measured by atomic absorption at 217.0 nm. The erythrocyte protoporphyrin was determined following extraction into 90% ethanol. The concentration of protoporphyrin in the blood of the lead exposed rat group was increased compared to that in the control group [12.46 +/- 0.57 (mean +/- S.D., n= 72) vs. 3.89 +/- 0.42, n=68, µmollL, p< 0.05]. The assay had excellent precision for both control and lead exposed groups (intra-assay and interassay coefficient of variation< 5%). The method was linear from 0.0 to 12.46 µmollL of erythrocyte protoporphyrin. A good relationship was obtained between erythrocyte protoporphyrin value and blood lead concentration. The results suggest that the erythrocyte protoporphyrin value obtained by this method could be used as a screening test for lead poisoning
کلیدواژه‌های انگلیسی مقاله Erythrocyte protoporphyrin, lead, poisoning.
نویسندگان مقاله دردی قوجق | durdi qujeq
from the department of biochemistry and biophysics, babol university of medical sciences, babol, i.r. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-322&slc_lang=en&sid=en
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