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Medical Journal of Islamic Republic of Iran، جلد ۱۴، شماره ۲، صفحات ۱۷۵-۱۸۰
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عنوان انگلیسی SUPPRESSION OF VLDL-TRIACYLGLYCEROL SECRETION B Y BOTH α AND β-ADRENOCEPTOR AGONISTS IN ISOLATED RAT HEPATOCYTES
چکیده انگلیسی مقاله The effects of alpha and beta-adrenergic stimulation on triacylglycerol secretion were investigated in isolated rat hepatocytes. Epinephrine within 3h of incubation suppressed triacylglycerol secretion by 35% and increased its cellular content by 18%. The inhibitory effect of epinephrine was abolished by inclusion of phentolamine and also prazosin but not with propranolol. Trifluoperazine concealed the inhibitory effect of epinephrine in a dose-dependent manner, whereas theobromine did not have any significant effect. The secretion of triacylglycerol was suppressed not only by the a-agonist phenylephrine but also by the β-agonist isoproterenol. Dibutyryl-cyclic AMP also inhibited secretion of triacylglycerol by approximately 30%. The results indicate that epinephrine suppressed triacylglycerol secretion via the α1-adrenoceptor whereas stimulation of beta-as well as alpha-adrenoceptors can exert a similar effect. Calcium-calmodulin dependent protein kinase may be involved in the down-regulation of VLDL secretion. The unexpected effect of isoproterenol has been discussed in relation to "dual signaling" and also the "store-dependent calcium entry" hypotheses.
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نویسندگان مقاله m رسولی | m rasouli
from the department of biochemistry. faculty of medicine, tehran university of medical sciences. tehran. and the

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m شریف | m sharif
dept. of mycology and parasitology. sari college of medical sciences, mazandaran university of medica sciences, sari. 1

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m زهرایی | m zahraie
from the department of biochemistry. faculty of medicine, tehran university of medical sciences. tehran. and the

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-338&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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